Calcium dobesilate ameliorates lung injury following lower limb ischemia/reperfusion

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dc.authorid0000-0002-6095-264Xen_US
dc.authorid0000-0001-7648-6324
dc.authorid0000-0002-8259-7896
dc.authorid0000-0002-2823-236X
dc.contributor.authorBozkurt, Ahmet Kürşat
dc.contributor.authorKonukoğlu, Dildar
dc.contributor.authorÜstündağ, Nil
dc.contributor.authorYüceyar, Lale
dc.contributor.authorMayda, Atilla Senih
dc.date.accessioned2021-06-23T19:17:28Z
dc.date.available2021-06-23T19:17:28Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractWe examined the effects of calcium dobesilate on ameliorating the lung damage following ischemia-reperfusion injury in skeletal muscle of rats. A well known antioxidant, dimethyl sulfoxide, was also tested for comparison. The study included three groups: normal saline, dimethyl sulfoxide and calcium dobesilate. Plasma bicarbonate, creatine kinase, lactate dehydrogenase, thiobarbituric acid reactive substances (TBARS), as well as muscle and lung tissue TBARS levels were measured. Lung tissue samples were taken for histological examination. The dimethyl sulfoxide group showed significant amelioration of plasma (p = 0.004), skeletal muscle (p = 0.006) and lung TBARS (p = 0.004) levels, compared with controls. Calcium dobesilate-treated rats showed significantly low level muscle (p = 0.025) and lung TBARS (p = 0.004), compared with the control group. The extent of lung injury according to the histological findings was less in the dimethyl sulfoxide (p = 0.004) and calcium dobesilate (p = 0.003) groups. These observations indicated that calcium dobesilate acted effectively in the prevention of lung damage following ischemia-reperfusion injury in the rat skeletal muscle.en_US
dc.identifier.endpage132en_US
dc.identifier.issn0378-6501
dc.identifier.issue4en_US
dc.identifier.pmid12512230en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5426
dc.identifier.volume28en_US
dc.identifier.wosWOS:000179963600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMayda, Atilla Senih
dc.language.isoenen_US
dc.publisherBioscience Ediprint Incen_US
dc.relation.ispartofDrugs Under Experimental And Clinical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcium Dobesilateen_US
dc.subjectIschemia/Reperfusion
dc.titleCalcium dobesilate ameliorates lung injury following lower limb ischemia/reperfusionen_US
dc.typeArticleen_US

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Dahili Tıp Bilimleri Bölümü Koleksiyonu
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