Investigation of celiac disease according to Marsh classification in childhood

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dc.authorid0000-0003-2469-9509en_US
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorÜnal, Fatih
dc.contributor.authorDemircioğlu, Fatih
dc.date.accessioned2021-06-23T19:48:55Z
dc.date.available2021-06-23T19:48:55Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Celiac disease (CD) is an autoimmune disorder of the small intestine related to gluten. CD is diagnosed by the evaluation of histologic findings according to the Marsh classification. Objectives: To evaluate the clinical and laboratory differences of CD according to Marsh classification. Patients and method: The records of >= Marsh 2 histologically diagnosed 132 cases were evaluated. Results: It was determined that 7(5.3%) cases were Marsh 2, 32(24.2%) were Marsh 3a, 73(55.3%) were Marsh 3b, and 20(15.1%) were Marsh 3c. Vomiting in Marsh 2 was significantly lower than Marsh 3b and Marsh 3c (respectively, 14.3% vs. 56.9%, p= 0.029; and 14.3% vs. 75%, p= 0.005). Hemoglobin was significantly higher in Marsh 2 than Marsh 3b and Marsh 3c (respectively, 11.9 +/- 1.7 vs. 10.5 +/- 1.6 g/dl, p= 0.038 and; 11.9 +/- 1.7 vs. 9.8 +/- 1.6 g/dl, p= 0.005). Positive detection ratio for tTG IgA was significantly lower in Marsh 2 than Marsh 3a, Marsh 3b and Marsh 3c (respectively, 66.7% vs. 100%, p< 0.001; 66.7% vs. 100%, p< 0.001; and 66.7% vs. 94.1%, p= 0.003). After the onset of gluten free diet, the time passed for the disappearance of tTG IgA seropositivity is significantly shorter in Marsh 2 than Marsh 3c (6 +/- 3.6 vs. 9.7 +/- 2.5 months, p= 0.017). Conclusions: Gastrointestinal symptoms are more frequent in patients with severe small intestinal mucosal injury. tTG IgA seropositivity is associated with more severe disease. Clinical and laboratory findings of the patients are exacerbated when histopathological findings improve in CD.en_US
dc.identifier.doi10.3329/bjms.v16i2.26700
dc.identifier.endpage265en_US
dc.identifier.issn2223-4721
dc.identifier.issn2076-0299
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85016183342en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage259en_US
dc.identifier.urihttps://doi.org/10.3329/bjms.v16i2.26700
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9254
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000405963200014
dc.identifier.volume16en_US
dc.identifier.wosWOS:000405963200014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorDemircioğlu, Fatih
dc.language.isoenen_US
dc.publisherIbn Sina Trusten_US
dc.relation.ispartofBangladesh Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCeliac Diseaseen_US
dc.subjectMarsh Classificationen_US
dc.subjectSerological Testsen_US
dc.subjectChildrenen_US
dc.titleInvestigation of celiac disease according to Marsh classification in childhooden_US
dc.typeArticleen_US

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