Relationship between bone mineral density and biochemical parameters in obese children and adolescents

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dc.authorid0000-0002-7213-5647en_US
dc.authorid0000-0001-8755-7714en_US
dc.authorid0000-0002-2092-3422en_US
dc.authorid0000-0001-9532-8241en_US
dc.contributor.authorBala, Mehmet Murat
dc.contributor.authorBala, Keziban A.
dc.contributor.authorPeker, Gökhan
dc.contributor.authorÜnsal, Seyyid Şerif
dc.contributor.authorGürler, Müjgan
dc.date.accessioned2024-02-15T11:46:10Z
dc.date.available2024-02-15T11:46:10Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: The aim of this study was to measure bone mineral density (BMD) using dual-energy X-Ray absorp-tiometry and to compare BMD-associated biochemical markers and evaluate their correlations with severity of obesity.METHODS: Overall, 102 obese children and adolescents were included to the study. The subjects were stratified into 2 groups according to severity of obesity as determined by BMI (Body Mass Index): obese group and severe obese group. For all subjects, data regarding height, weight, BMI and levels of calcium, phosphorus, alkaline phosphatase, 25-OH vitamin D, parathyroid hormone, cholesterol, triglyceride, fasting blood glucose, insulin, HOMA-IR and HbA1c were extracted from patient charts. The BMD was measured using dual-energy X-Ray absorptiometry. The BMD Z-scores were calculated using race-and gender-specific curves.RESULTS: The mean BMD Z-scores were within normal range in obese and severe obese groups with no significant difference between groups. The bone density was found to be >-2.0 Z-score in all subjects. However, when subjects were stratified according to BMD Z-scores as those with BMD Z-score of-2.0-0 and those with >0, it was found that BMI was significantly correlated with BMD Z-score. In BMD Z-score discrimination, it was found that vitamin 25-OHD also showed significant difference. Among dyslipidemia parameters, a significant, positive correlation was detected between LDL-cholesterol and BMD Z-score in the group with BMD Z-score >0. A significant negative correlation was detected between BMD Z-score and HOMA-IR and HbA1c in the group with BMD Z-score <0CONCLUSIONS: In our study, it was found that glucose as well as some lipid metabolism markers could have significant association with BMD in obese children. Although BMI was associated with BMD in obese children with BMD Z-score >0, there was no such association in those with BMD Z-score <0. (Cite this article as: Bala MM, Bala KA, Peker G, Unsal SS, Giirler M. Relationship between bone mineral density and biochemical parameters in obese children and adolescents. Gazz Med Ital -Arch Sci Med 2022;181:315-23. DOI: 10.23736/ S0393-3660.20.04522-2)en_US
dc.identifier.citationBala, M. E. H. M. E. T., Bala, K., Peker, G., Ünsal, S., & Gürler, M. (2022). Relationship between bone mineral density and biochemical parameters in obese children and adolescents. Gazzetta Medica Italiana Archivio per le Scienze Mediche, 181(5).en_US
dc.identifier.doi10.23736/S0393-3660.20.04522-2
dc.identifier.endpage323en_US
dc.identifier.issn0393-3660
dc.identifier.issn1827-1812
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage315en_US
dc.identifier.urihttp://dx.doi.org/10.23736/S0393-3660.20.04522-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12026
dc.identifier.volume181en_US
dc.identifier.wosWOS:000887249800003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGürler, Müjgan
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofGazzetta Medica Italiana Archivio Per Le Scienze Medicheen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectBone Densityen_US
dc.subjectInsulin Resistanceen_US
dc.subjectVıtamın-D Statusen_US
dc.subjectBody-Massen_US
dc.subjectDeterminanten_US
dc.titleRelationship between bone mineral density and biochemical parameters in obese children and adolescentsen_US
dc.typeArticleen_US

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