Sex steroid levels and stress-related markers in pregnant and non-pregnant women and the effect of periodontal therapy

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dc.authoridUCAN YARKAC, Fatma/0000-0001-8126-585X
dc.contributor.authorGokturk, Ozge
dc.contributor.authorYarkac, Fatma Ucan
dc.contributor.authorAvcioglu, Fatma
dc.date.accessioned2024-09-25T19:58:36Z
dc.date.available2024-09-25T19:58:36Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Periodontal disease during pregnancy can produce adverse events; in the current study stress was investigated as an exacerbating factors of periodontal disease. The aims of this study were to evaluate the possible associations between stress and pregnancy through scanning for gingivitis and to explore the effect of non-surgical periodontal therapy (NPT) on stress-related markers (CgA, AA, beta-endorphin, DHEA, sIgA and NPY) and sex steroid levels (estrogen and progesterone) in pregnant and non-pregnant women. Material and methods: A total of 87 subjects; 22 pregnant women with gingivitis, 25 periodontally healthy pregnant women; 22 non-pregnant women with gingivitis and 15 periodontally healthy non-pregnant women, participated in this study. Periodontal clinical measures, stress hormones and sex steroid levels were measured at baseline and following the periodontal therapy. Results: While periodontal therapy showed an improvement in salivary CgA, AA, beta-endorphin, DHEA, and sIgA levels (p<0.05) in non-pregnant women with gingivitis; neuropeptide Y levels were found to be unaffected (p>0.05). There were no significant changes in salivary CgA, AA, DHEA, sIgA, and neuropeptide Y levels in pregnant women with gingivitis (p>0.05); however, a decrease in beta-endorphin levels was observed after therapy (p<0.05). Pregnant women with gingivitis had higher gingival crevicular fluid (GCF) beta-endorphin levels in comparison to non-pregnant women with gingivitis. Conclusions: Gingival inflammation can be a psychosocial stress inducing factor during pregnancy. Furthermore, periodontal therapy may assist in reducing stress-related hormone levels in GCF during pregnancy.en_US
dc.description.sponsorshipScientific Research Projects Office, Bolu, Turkey [2018.06.05.1298]en_US
dc.description.sponsorshipFunding The study was supported by the Bolu Abant Izzet Baysal Universityr Scientific Research Projects Office, Bolu, Turkey with the project number 2018.06.05.1298.en_US
dc.identifier.doi10.4317/medoral.26455
dc.identifier.endpagee491en_US
dc.identifier.issn1698-6946
dc.identifier.issue4en_US
dc.identifier.pmid38368525en_US
dc.identifier.scopus2-s2.0-85197350134en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpagee483en_US
dc.identifier.urihttps://doi.org/10.4317/medoral.26455
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13646
dc.identifier.volume29en_US
dc.identifier.wosWOS:001263095700005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedicina Oral S Len_US
dc.relation.ispartofMedicina Oral Patologia Oral Y Cirugia Bucalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectGingival crevicular fluiden_US
dc.subjectgingivitisen_US
dc.subjectnon-surgical periodontal therapyen_US
dc.subjectpregnancyen_US
dc.subjectsalivaen_US
dc.titleSex steroid levels and stress-related markers in pregnant and non-pregnant women and the effect of periodontal therapyen_US
dc.typeArticleen_US

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