Relationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients
dc.authorid | 0000-0001-6854-2197 | en_US |
dc.authorid | 0000-0001-7616-3330 | en_US |
dc.authorid | 0000-0002-5315-122X | en_US |
dc.authorid | 0000-0003-1148-2247 | en_US |
dc.authorid | 0000-0001-7573-0882 | en_US |
dc.contributor.author | Doğan, Serdar | |
dc.contributor.author | Okuyan, Hamza Malik | |
dc.contributor.author | Bal, Tayibe | |
dc.contributor.author | Çabalak, Mehmet | |
dc.contributor.author | Begen, Mehmet A | |
dc.date.accessioned | 2024-07-09T11:07:03Z | |
dc.date.available | 2024-07-09T11:07:03Z | |
dc.date.issued | 2023 | en_US |
dc.department | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.description.abstract | Objectives: Roles of Thrombospondin-1 (TSP-1) and Thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear. We investigate the roles of TSP-1 and TSP-2 in COVID-19. Methods: 106 SARS-CoV-2 infected patients and 23 healthy people were enrolled in our study. COVID-19 patients were divided into two groups as non-severe and severe. TSP-1 and TSP-2 concentrations were measured with an enzyme-linked Immunosorbent Assay, and blood markers were analyzed with routine laboratory techniques. Results: COVID-19 patients had significantly higher TSP-1 and TSP-2 levels than healthy controls. TSP-1 and TSP-2 positively correlated with inflammatory markers, including ESR, CRP, PCT, ferritin, and biochemical parameters such as ALT, AST, BUN, CK, and LDH. In addition, TSP-1 and TSP-2 were negatively correlated with hematological markers such as LYM, EOS, and HGB. Receiver operating characteristic analyses revealed that COVID-19 may be predicted with TSP-1 levels over 189.94 ng/mL and TSP-2 levels higher than 0.70 ng/mL. Conclusions: Our analysis suggests that TSP-1 and TSP-2 expressions at the systemic level may have clinical importance for COVID-19. | en_US |
dc.identifier.citation | Dogan, S., Okuyan, H. M., Bal, T., Çabalak, M., & Begen, M. A. (2023). Relationship of thrombospondin-1 and thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients. Turkish Journal of Biochemistry, 48(4), 368-375. | en_US |
dc.identifier.doi | 10.1515/tjb-2022-0265 | |
dc.identifier.endpage | 375 | en_US |
dc.identifier.issn | 0250-4685 | |
dc.identifier.issn | 1303-829X | |
dc.identifier.issue | 4 | en_US |
dc.identifier.scopus | 2-s2.0-85173871650 | en_US |
dc.identifier.scopusquality | Q4 | en_US |
dc.identifier.startpage | 368 | en_US |
dc.identifier.trdizinid | 1252069 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1515/tjb-2022-0265 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/12247 | |
dc.identifier.volume | 48 | en_US |
dc.identifier.wos | WOS:001019169100001 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | TR-Dizin | en_US |
dc.institutionauthor | Bal, Tayibe | |
dc.language.iso | en | en_US |
dc.publisher | Walter De Gruyter GMBH | en_US |
dc.relation.ispartof | Turkish Journal of Biochemistry-Türk Biyokimya Dergisi | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Biomarker | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Thrombospondin-1 | en_US |
dc.subject | Thrombospondin-2 | en_US |
dc.title | Relationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients | en_US |
dc.type | Article | en_US |