Serum level of nt-probnp as an early cardiac marker of carbon monoxide poisoning
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Tarih
2006
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction Acute carbon monoxide (CO) poisoning may cause cardiotoxicity. The natriuretic peptides that include atrial natriuretic peptide, brain natriuretic peptide (BNP), N-BNP and NT-proBNP are endogenous cardiac hormones that may be secreted upon myocardial stress [1]. The aim of this study was to assess the plasma NT-proBNP level in acute CO poisoning, and to compare it with healthy controls.
Material and methods After approval of the ethical committee, patients with the diagnosis of carbon monoxide poisoning were studied. Echocardiography was performed to all patients [2–4]. Serum NT-pro BNP, creatine kinase (CK), creatine kinase-MB (CK-MB) and Troponin-T were also analyzed together with the carboxyhemoglobin (COHb) level. The correlation between serum NT-pro BNP and COHb level was investigated. All tests were performed other than COHb in the blood of healthy volunteers. Electrocardiograms were performed in all patients and healthy controls, and the results were compared.
Results Troponin, CK and CK-MB levels were statistically insignificant between both groups (P>0.05). The level of NT-proBNP and COHb were found to be increased in the study group. A positive correlation was found between the COHb and the NT-proBNP (r=0.829, P<0.01), and between the COHb and the CK (r=0.394, P<0.01). No difference was observed in other parameters between groups all of which were within normal range.
Conclusion We conclude that, being an early increasing marker, measuring the plasma NT-proBNP level may contribute to the early diagnosis of cardiotoxicity in patients with carbon monoxide poisoning, contributory to the conventional methods
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Kaynak
European Journal of Emergency Medicine
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
13
Sayı
5
