Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis

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dc.authoridToprak, Tuncay/0000-0003-1348-5273
dc.authoridDurairajanayagam, Damayanthi/0000-0001-9049-0215
dc.authoridSokolakis, Ioannis/0000-0002-1938-8004
dc.authoridFINOCCHI, FEDERICA/0000-0003-1551-5990
dc.authoridRusso, Giorgio Ivan/0000-0003-4687-7353
dc.authoridVishwakarma, Ranjit/0000-0002-6784-2830
dc.authoridHamoda, Taha/0000-0002-8070-4088
dc.contributor.authorRusso, Giorgio Ivan
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorFinocchi, Federica
dc.contributor.authorJuma, Almas Ramadhani
dc.contributor.authorDurairajanayagam, Damayanthi
dc.contributor.authorKahraman, Oguzhan
dc.contributor.authorSogutdelen, Emrullah
dc.date.accessioned2024-09-25T19:58:40Z
dc.date.available2024-09-25T19:58:40Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractPurpose: Varicocele has been associated with high seminal oxidative stress (OS), impaired semen quality, and reduced male fertility potential. However, the exact mechanism(s) underlying the development of varicocele-mediated infertility and the cause -effect relationship between varicocele and testicular dysfunction are not fully understood. The aim of this systematic review and meta -analysis (SRMA) is to investigate the impact of varicocele on testicular OS markers and sperm parameters in experimental animals with varicocele as compared to animals without varicocele. Materials and Methods: A literature search was performed using the Scopus and PubMed databases on studies that investigated testicular OS markers and sperm parameters in animals with varicocele. The primary outcomes included malondialdehyde (MDA) (nmol/mg) levels whereas the secondary outcomes included total sperm count (x106), sperm vitality (%), total sperm motility (%), and sperm DNA fragmentation (SDF) (%). Standardized mean difference (SMD) (95% confidence interval [CI]) was chosen to express the effect size. The quality of the included studies was evaluated using the Cambridge Quality Checklist. Results: Out of 76 identified articles, 6 studies on rats were included in the meta -analysis. The analysis showed a significant increase of MDA (SMD: 15.61 [1.93, 29.29]; p=0.03) in rats with varicocele vs. controls. We also observed a significant decrease in total sperm count (SMD: -17.45 [-28.97, -5.93]; p<0.01), sperm vitality (SMD: -16.41 [-26.30, -6.52]; p<0.01), total sperm motility (SMD: -17.67 [-24.90, -10.44]; p<0.01), and a significant increase of SDF (SMD: 7.41 [1.23, 13.59]; p=0.02), in rats with varicocele vs. controls. The quality of the included studies was ranked as high. Conclusions: This SRMA indicates a significant increase in levels of testicular MDA and SDF and a reduction of sperm quality in experimental animals with varicocele. These findings support the potential role of testicular OS in the development of varicocele-induced testicular damage.en_US
dc.identifier.doi10.5534/wjmh.230260
dc.identifier.endpage573en_US
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.issue3en_US
dc.identifier.pmid38449451en_US
dc.identifier.scopus2-s2.0-85193415964en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.5534/wjmh.230260
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13698
dc.identifier.volume42en_US
dc.identifier.wosWOS:001163725800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSokolakis, Ioannis
dc.language.isoenen_US
dc.publisherKorean Soc Sexual Medicine & Andrologyen_US
dc.relation.ispartofWorld Journal of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectInfertilityen_US
dc.subjectOxidative stressen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectSpermatozoaen_US
dc.subjectVaricoceleen_US
dc.titleImpact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysisen_US
dc.typeReview Articleen_US

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