The relation of methicillin-resistance to growth time in staphylococci

Basit Öğe Kaydı
dc.authorid0000-0003-0727-1797
dc.authorid0000-0001-8781-1401
dc.contributor.authorTopkaya, Aynur Eren
dc.contributor.authorGüneş, Hayati
dc.contributor.authorGümüş, Abdullah
dc.contributor.authorTaş, Tekin
dc.contributor.authorMengeloğlu, Fırat Zafer
dc.date.accessioned2021-06-23T19:34:56Z
dc.date.available2021-06-23T19:34:56Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: With the biochemical and molecular studies on penicillin-binding proteins associated with methicillin-resistance in staphylococci the determination and interpretation of the resistance have been changed. Particularly careful evaluation of staphylococci isolated from blood cultures before instituting therapy is of utmost significance in regard to morbidity and mortality. One of the important criteria of this evaluation is the growth tune of staphylococci. The purpose of this study was to determine the relation of methicillin-resistance to growth time in Staphylococcus aureus and methicillin-resistant staphylococci. Methods: The study was carried on a total of 66 clinical isolates of staphylococci including 18 methicillin-susceptible Staphylococcus aureus (MSSA), 14 methicillin-resistant Staphylococcus aureus (MRSA), 19 methicillin-susceptible coagulase-negatiye staphylococci (MSCNS) and 15 methicillin-resistant coagulase-negative staphylococci (MRCNS). Following growth on subculture under similar conditions, all isolates were inoculated in equal quantities into hemoculture bottles, the optimum time-of-positivity in minutes for each isolate was calculated, and the growth times of the 4 isolate groups were statistically compared. Results: The longest growth time was detected in MRCNS. The growth time was longer in MRSA and MRCNS than in MSSA and MSCNS, respectively; however, a statistically significant difference was observed between MRCNS and MSCNS isolates. Conclusion: In conclusion, it is known that in methicillin resistant Staphylococcus aerus, PBP2a which is responsible for methicillin resistance takes over the role penicillin-binding protein of PBP1. PBP2 and PBP3 in peptidoglycan synthesis. But, other possible factors affecting the resistance mechanisms or growth time of MRCNS should be investigated.en_US
dc.identifier.endpage696en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84896710536en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage693en_US
dc.identifier.urihttps://www.actamedicamediterranea.com/archive/2013/medica-4/the-relation-of-methicillin-resistance-to-growth-time-in-staphylococci
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7667
dc.identifier.volume29en_US
dc.identifier.wosWOS:000330151200015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaş, Tekin
dc.institutionauthorMengeloğlu, Fırat Zafer
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectCoagulase-Negative Staphylococcien_US
dc.subjectMethicillin-Resistanceen_US
dc.subjectGrowth Timeen_US
dc.titleThe relation of methicillin-resistance to growth time in staphylococcien_US
dc.typeArticleen_US

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