Possible cytoprotective potential of ruthenium red in evaluation of the rapid apoptotic model induced by H2O2

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dc.authorid0000-0001-9589-4091
dc.authorid0000-0002-5650-1280
dc.contributor.authorBayram, Recep
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorDüzenli, Selma
dc.contributor.authorGepdiremen, Akçahan
dc.date.accessioned2021-06-23T19:28:13Z
dc.date.available2021-06-23T19:28:13Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIn the present paper, hydrogen peroxide (H2O2) induced an apoptotic process in 1 h and over the doses of 10 mM, while cisplatin did not, in cortical neuronal homogenates of rats. It was proved in DNA fragmentation, MTT and WST-1 assays. Especially, according to WST-1 assay results, apoptotic effect was decided to be very obvious in all tests in the doses of 20 mM of the rapid model of apoptosis of H2O2. Ruthenium red, as a mitochondrial Ca2+ modulator, was tested alone and co-application with H2O2. Without H2O2, at low doses of it, ruthenium red seems to have a slight viability inducing effect in respect to controls in MTT and WST-1, despite that this effect was not observed clearly in DNA fragmentation test. Another point is that the highest dose of ruthenium red (10 M), induces apoptosis, even stronger than the 20 mM H2O2, controversy to the general believing.en_US
dc.identifier.endpage1798en_US
dc.identifier.issn0970-7077
dc.identifier.issn0975-427X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-79952133628en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1795en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6975
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79952133628&partnerID=40&md5=efb6abd3dd7e854e365af77c41927b85
dc.identifier.volume23en_US
dc.identifier.wosWOS:000288465100092en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBayram, Recep
dc.institutionauthorYavuz, Muhsine Zeynep
dc.institutionauthorDüzenli, Selma
dc.institutionauthorGepdiremen, Akçahan
dc.language.isoenen_US
dc.publisherAsian Journal Of Chemistryen_US
dc.relation.ispartofAsian Journal Of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectMitochondriaen_US
dc.subjectH2O2en_US
dc.subjectCisplatinen_US
dc.subjectRuthenium Reden_US
dc.subjectDNA Fragmentationen_US
dc.titlePossible cytoprotective potential of ruthenium red in evaluation of the rapid apoptotic model induced by H2O2en_US
dc.typeArticleen_US

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