The right ventricle outflow tract systolic function could predict the severity of the cirrhosis

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dc.authoridAcar, Emrah/0000-0001-8535-2336
dc.contributor.authorDonmez, Ibrahim
dc.contributor.authorCan, Guray
dc.contributor.authorAcar, Emrah
dc.date.accessioned2024-09-25T19:57:25Z
dc.date.available2024-09-25T19:57:25Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground/aim: The distinctive liver framework is converted into structurally abnormal nodules as a consequence of tissue fibrosis in cirrhosis. Cardiac dysfunction in cirrhosis was described, and the term cirrhotic cardiomyopathy (CCM) was coined to describe this syndrome. Recent research has shown that the contractile characteristics of the right ventricular outflow tract (RVOT) have a significant impact on right ventricular functions. The right ventricular outflow tract -systolic excursion is an important systolic function marker of RVOT (RVOT-SE). There has yet to be published research on RVOT function in cirrhotic patients. We looked at the relationship between cirrhosis severity and the RVOT-SE. Materials and methods: Sixty-nine consecutive hepatic cirrhotic patients were recruited for the research between June 1, 2018 and January 1, 2022. A medical history, thorough physical examination, laboratory investigations, echocardiographic evaluation, and RVOT-SE were obtained. The patients were separated into two groups: those with compensated cirrhosis (Child -Pugh class 1) and those with decompensated cirrhosis (Child -Pugh class 2 and 3). Results: On the numerous standard echocardiographic parameters that examined the diameter and function of the left ventricle, we observed no significant difference between groups. Nevertheless, a statistically significant difference in Right Ventricle Wall (RVW) (p = 0.014), systolic pulmonary artery pressure (sPAP) (p = 0.034), RVOT-SE (p = 0.003), and Tricuspid Annular Plane Systolic Excursion (TAPSE) (p = 0.042) was detected across cirrhosis groups. The RVOT-SE had a positive correlation with cirrhosis severity (OR: 0.607; 95% CI: 0.425-0.866; p = 0.006), according to multiple logistic regression studies. According to the ROC curve study, RVOT-SE 8.8 cm/s predicted decompensated cirrhosis with 72% sensitivity and 72.7% specificity (AUC = 0.715, p: 0.001). Conclusion: In the current study, we found that RVOT-SE was related to the severity of cirrhosis. Larger patient cohorts and multicenter investigations will provide light on the notion.en_US
dc.identifier.doi10.55730/1300-0144.5785
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid38812635en_US
dc.identifier.scopus2-s2.0-85185699725en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5785
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13410
dc.identifier.volume54en_US
dc.identifier.wosWOS:001171489500004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectChild-Turcotte-Pughen_US
dc.subjectcirrhosisen_US
dc.subjectechocardiographyen_US
dc.subjectoutflow tracten_US
dc.subjectright ventricleen_US
dc.subjectsystoleen_US
dc.titleThe right ventricle outflow tract systolic function could predict the severity of the cirrhosisen_US
dc.typeArticleen_US

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