Western diet induces endogen oxidative deoxyribonucleic acid damage and inflammation in Wistar rats

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dc.authorid0000-0002-3344-6637
dc.authorid0000-0002-4107-5389
dc.contributor.authorYener, Yeşim
dc.contributor.authorYerlikaya, Fatma Hümeyra
dc.date.accessioned2021-06-23T19:49:44Z
dc.date.available2021-06-23T19:49:44Z
dc.date.issued2018
dc.departmentBAİBÜ, Eğitim Fakültesi, Temel Eğitim Bölümüen_US
dc.description.abstractObjective Nutritional diseases such as metabolic syndrome, cardiovascular disorder, chronic inflammation or even cancer are observed in people who sustain their lifestyle by Western diet due to high calorie intake. The origin of these diseases are the degraded deoxyribonucleic acid structure. In this study, we investigated whether Western diet produced endogenous oxidative deoxyribonucleic acid damage, apoptosis or inflammation. Methods Twenty-eight male Wistar rats, aged 10-12 weeks, were divided into four groups. The rats in control group received the standard diet and the remaining rats were given one of the following three diets for four weeks: a high-fat diet containing 35% fat, a high-sucrose diet containing 69% sucrose and Western diet comprising both two types of diets. After treatment the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1, chitinase-3-like protein 1, soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels were measured. Results It was observed no changes in the serum soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels whereas a statistically significant increase in the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1 and chitinase-3-like protein 1 levels were found only in rats that were given Western diet. Conclusion The findings show that Western diet produced endogenous oxidative deoxyribonucleic acid damage, which then increased serum poly (adenosine diphosphate ribose) polymerase-1 levels, eventually leading to inflammation.en_US
dc.identifier.doi10.1590/1678-98652018000300001
dc.identifier.endpage273en_US
dc.identifier.issn1415-5273
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85054874566en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage263en_US
dc.identifier.urihttps://doi.org/10.1590/1678-98652018000300001
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9599
dc.identifier.volume31en_US
dc.identifier.wosWOS:000446344500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYener, Yeşim
dc.language.isoenen_US
dc.publisherPontificia Universidade Catolica Campinasen_US
dc.relation.ispartofRevista De Nutricao-Brazilian Journal Of Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectDeoxyribonucleic Aciden_US
dc.subjectInflammationen_US
dc.subjectDiet Westernen_US
dc.subjectOxidative Stress Damageen_US
dc.titleWestern diet induces endogen oxidative deoxyribonucleic acid damage and inflammation in Wistar ratsen_US
dc.typeArticleen_US

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