The association between sodium citrate cotransporter (NaDC-1) gene polymorphism and urinary citrate excretion in patients with calcium-containing kidney stones

Basit Öğe Kaydı
dc.authorid0000-0001-9589-4091en_US
dc.authorid0000-0003-0328-8444en_US
dc.authorid0000-0002-6988-0806en_US
dc.contributor.authorÇalışkan, Ahmet
dc.contributor.authorMemik, Ömür
dc.contributor.authorDüzenli, Selma
dc.contributor.authorTekin, Ali
dc.date.accessioned2024-06-26T11:44:31Z
dc.date.available2024-06-26T11:44:31Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate the relationship between sodium citrate cotransporter (NaDC-1) gene polymorphism and urinary citrate excretion in patients with kidney stones containing calcium. Materials and Methods: Between June 2009 and August 2011, stone materials obtained from patients treated for nephrolithiasis at the Urology Clinic were examined using X-ray diffraction, and patients with calcium-containing stones (calcium oxalate and calcium phosphate) were identified. Patients were divided into two groups based on their 24-hour urine citrate levels: (1) those with normal urine citrate levels and (2) hypocitraturia. To analyze the rs11567842 mutation in the NaDC-1 gene, their blood was collected in a Na-EDTA hemogram tube and stored at -40 degrees C. The genotypes of the cases were determined by analyzing the obtained genomic DNAs in real-time polymerase chain reaction. Results: Ninety-six patients with calcium-containing nephrolithiasis were eligible for this study, 40 with normal urine citrate levels and 56 with hypocitraturia. The mean 24-hour urine citrate levels in the normal- and hypo-citraturia groups were 773 mg/1.73 m(2)/24 hours and 152 mg/1.73 m(2)/24 hours, respectively. Citrate measurements revealed a statistically significant difference between the two groups (p<0.001). Twenty-fourhour urine oxalate, magnesium, calcium, and uric acid levels did not differ significantly between the groups (all p>0.05). NaDC-1 gene rs11567842 homozygous mutation (GG genotypes) was detected in 4 (10%) of normocitraturia and 4 (7%) of hypocitraturia. The normocitraturia group had a higher mutation rate than the hypocitraturia group, but this difference was insignificant (p=0.618). Conclusion: This study suggests that the NaDC-1 gene polymorphism does not cause hypocitraturia in calcium-containing kidney stones. Larger studies are needed to understand genetic disorders' impact on low urinary citrate excretion, with patient groups and healthy controls, and a standard diet.en_US
dc.identifier.citationCaliskan, A., Memik, O., Duzenli, S., & Tekin, A. (2023). The Association Between Sodium Citrate Cotransporter (NaDC-1) Gene Polymorphism and Urinary Citrate Excretion in Patients with Calcium-containing Kidney Stones. Journal of Urological Surgery, 10(4), 290-295.en_US
dc.identifier.doi10.4274/jus.galenos.2023.2023-10-2
dc.identifier.endpage294en_US
dc.identifier.issn2148-9580
dc.identifier.issue4en_US
dc.identifier.startpage290en_US
dc.identifier.trdizinid1255575en_US
dc.identifier.urihttp://dx.doi.org/10.4274/jus.galenos.2023.2023-10-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12222
dc.identifier.volume10en_US
dc.identifier.wosWOS:001122443400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDüzenli, Selma
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Urological Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCitrateen_US
dc.subjectHypocitraturiaen_US
dc.subjectNaDC-1en_US
dc.subjectPolymorphismen_US
dc.subjectKidney Stoneen_US
dc.subjectUrolithiasisen_US
dc.titleThe association between sodium citrate cotransporter (NaDC-1) gene polymorphism and urinary citrate excretion in patients with calcium-containing kidney stonesen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu