Effects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized rats

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dc.authorid0000-0003-1730-6463
dc.authorid0000-0001-5073-0691
dc.authorid0000-0001-5969-923X
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorEkerbiçer, Nuran
dc.contributor.authorSuveren, Eylem
dc.contributor.authorBikmaz, Sevda P.
dc.date.accessioned2021-06-23T18:54:50Z
dc.date.available2021-06-23T18:54:50Z
dc.date.issued2002
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractA short episode of ischemia induced by coronary artery occlusion can precondition the myocardium against arrhythmia. The factors that have the potential to protect the myocardium from subsequent ischemia and reperfusion are controversial. In this study, the pre-conditioning-like effects of adrenaline were investigated in both anesthetized and conscious rats. Adrenaline 0.1 and 0.5 mg/kg or saline was administered 10 min before coronary occlusion in conscious and anesthetized rats. The 0.5 mg/kg dose of adrenaline decreased the total duration of arrhythmia in both models. The incidence of ventricular fibrillation decreased and survival rate increased only in conscious rats administered 0.5 mg/kg adrenaline. As a result, it is suggested that exogenous administration of adrenaline before coronary ligation may precondition and protect the heart against arrhythmia.en_US
dc.identifier.endpage24en_US
dc.identifier.issn1205-6626
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0036524469en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4593
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0036524469&partnerID=40&md5=86a4a32c04be8a796158a1c5f1f0ba81
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBozdoğan, Ömer
dc.institutionauthorSuveren, Eylem
dc.language.isoenen_US
dc.relation.ispartofExperimental and Clinical Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenaline Pretreatmenten_US
dc.subjectArrhythmiaen_US
dc.subjectCoronary Occlusionen_US
dc.subjectPreconditioningen_US
dc.titleEffects of adrenaline pretreatment on the arrhythmias observed following ischemia and reperfusion in conscious and anesthetized ratsen_US
dc.typeArticleen_US

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