The effect of octreotide on portal vein and peritoneal fluid cytokine levels in postoperative adhesion prevention

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dc.authorid0000-0001-6990-185X
dc.contributor.authorGünal, Ömer
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorAslaner, Arif
dc.contributor.authorGhadouri, Salah
dc.date.accessioned2021-06-23T18:54:21Z
dc.date.available2021-06-23T18:54:21Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The aim of this study is to investigate the effect of octreotide on portal vein and peritoneal fluid TNF-? and IL-6 levels in the postoperative adhesion formation. Material and Methods: Following an "adhesion model operation", 10 rats were given octreotide subcutaneously (25 ?g/kg/day) for 10 days (study group) while other 10 rats did not receive any treatment (control group). Ten rats had only a midline laparotomy as sham. Adhesion scores, portal vein and peritoneal fluid cytokine levels were determined on the postoperative 10th day. Results: Octreotide significantly reduced the total adhesion score. It has also reduced the portal vein IL-6 and TNF-? (147 ± 2 pg/mL; 146.7 ± 2.6 pg/mL respectively) levels as compared to those of control group (193.5 ± 10 pg/mL; 195.8 ± 11.2 pg/mL respectively). There was no reduction (IL-6 132; 143 and TNF-? 132.8; 143.7) on contrary, elevations in peritoneal fluid cytokine levels, comparing to control. Conclusion: Octreotide reduces postoperative intraabdominal adhesion formation through the mechanisms those mediated by intestinal rather than peritoneal cytokine production. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage257en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33745797728en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage252en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4387
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33745797728&partnerID=40&md5=7cccbea2f5534f5676d341aba6b28449
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGünal, Ömer
dc.institutionauthorAslaner, Arif
dc.institutionauthorGhadouri, Salah
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectCytokineen_US
dc.subjectOctreotideen_US
dc.titleThe effect of octreotide on portal vein and peritoneal fluid cytokine levels in postoperative adhesion preventionen_US
dc.typeArticleen_US

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