The effect of octreotide on portal vein and peritoneal fluid cytokine levels in postoperative adhesion prevention
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study is to investigate the effect of octreotide on portal vein and peritoneal fluid TNF-? and IL-6 levels in the postoperative adhesion formation. Material and Methods: Following an "adhesion model operation", 10 rats were given octreotide subcutaneously (25 ?g/kg/day) for 10 days (study group) while other 10 rats did not receive any treatment (control group). Ten rats had only a midline laparotomy as sham. Adhesion scores, portal vein and peritoneal fluid cytokine levels were determined on the postoperative 10th day. Results: Octreotide significantly reduced the total adhesion score. It has also reduced the portal vein IL-6 and TNF-? (147 ± 2 pg/mL; 146.7 ± 2.6 pg/mL respectively) levels as compared to those of control group (193.5 ± 10 pg/mL; 195.8 ± 11.2 pg/mL respectively). There was no reduction (IL-6 132; 143 and TNF-? 132.8; 143.7) on contrary, elevations in peritoneal fluid cytokine levels, comparing to control. Conclusion: Octreotide reduces postoperative intraabdominal adhesion formation through the mechanisms those mediated by intestinal rather than peritoneal cytokine production. Copyright © 2006 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Adhesion, Cytokine, Octreotide
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
3
