Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample

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dc.authoriduyarel, huseyin/0000-0001-9931-5456
dc.contributor.authorOnat, Altan
dc.contributor.authorHergenc, Gulay
dc.contributor.authorUyarel, Huseyin
dc.contributor.authorOzhan, Hakan
dc.contributor.authorEsen, A. Metin
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorAlbayrak, Sinan
dc.date.accessioned2024-09-25T19:57:40Z
dc.date.available2024-09-25T19:57:40Z
dc.date.issued2007
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAims: The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60-89.9 ml/min/1.73 m(2)) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails. Methods: After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III. Results: In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant. Conclusion: Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000100487
dc.identifier.endpage96en_US
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue2en_US
dc.identifier.pmid17347575en_US
dc.identifier.scopus2-s2.0-34247626158en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://doi.org/10.1159/000100487
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13545
dc.identifier.volume30en_US
dc.identifier.wosWOS:000246044800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Gunay
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofKidney & Blood Pressure Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectdyslipidemiaen_US
dc.subjectglomerular filtration rateen_US
dc.subjectkidney dysfunctionen_US
dc.subjectinsulin resistanceen_US
dc.subjectmetabolic syndromeen_US
dc.titleAssociation between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sampleen_US
dc.typeArticleen_US

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