Effects of extra corporeal shock wave lithotripsy on portal vein cytokine levels, and liver
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medimond S R L
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We aimed to determine the effect of shock waves on the liver tissue, as well as on the portal vein IL-6 and TNF alpha levels.. The rats in the control group (n:10) did not receive any shock waves, while other rats (n:10) received 1000 shock waves. Twenty four hours after administration of shock waves all rats were sacrified and livers were taken out for histopathological evaluation. In addition portal vein IL-6 and TNF alpha serum levels were assayed. The mean IL-6 and TNF alpha levels of rats receiving shock waves ESWL were 276+/-10,7 pg / mi and 230+/-12,8 pg/ml respectively, These were significantly higher than that of the control group (p<0,05). The mean liver damage scores in this group (3,3+/-0,3) was also significantly higher than the control group (0,3+/-0,1; p<0.01), Histopathological examination of the livers revealed mild venous congestion, kupper cell hyperplesia, and erythrocyte extravasation in the sinusoids. As the safety range of shock wave administration to liver seems to be narrow we suggest low dose treatment for intrahepatic bile stones. In addition, early cytokine levels might be good indicators of the tissue damage, and guide us to determine the safety margin of shock wave administration.
Açıklama
Eurosurgery 2000 Meeting -- JUN 21-24, 2000 -- ISTANBUL, TURKEY
Anahtar Kelimeler
Extra Corporeal Shock, Lithotripsy
Kaynak
Proceedings Eurosurgery 2000
WoS Q Değeri
N/A
