The levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis

Basit Öğe Kaydı
dc.authorid0000-0003-0411-9669en_US
dc.authorid000000333957178
dc.authorid0000-0001-5299-7250
dc.authorid0000-0003-4178-8730
dc.contributor.authorTekeoğlu, İbrahim
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorSağ, Sinem
dc.contributor.authorHarman, Halil
dc.contributor.authorAltındiş, Mustafa
dc.date.accessioned2021-06-23T19:43:31Z
dc.date.available2021-06-23T19:43:31Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnnual European Congress of Rheumatology (EULAR) -- JUN 08-11, 2016 -- London, ENGLANDen_US
dc.description.abstractObjective: The aim of this study was to investigate the relationship between disease severity and bio- chemical parameters such as pentraxin-3, fetuin-A, IL-6, insulin and HOMA-IR levels in patients with rheumatoid arthritis. Methods: This study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were measured. Also, HOMA-IR values were calculated. Disease activity was assessed with Disease Activity Score (DAS28). To evaluate quality of life, the Health Assessment Questionnaire disability index was applied. Results: The serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were found to be higher than control subjects (p values = 0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively). A positive cor- relation was evident between the DAS 28 score and IL6 levels (r = 0.263, p = 0.045). We found no corre- lation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p < 0.05). Fetuin A levels were positively correlated with cumulative steroid dose (r = 0.382, p = 0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r = 0.437, p = 0.032). Conclusion: Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA.en_US
dc.identifier.doi10.1136/annrheumdis-2016-eular.1744
dc.identifier.endpage196en_US
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.1136/annrheumdis-2016-eular.1744
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8796
dc.identifier.volume75en_US
dc.identifier.wosWOS:000401523101033en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorHarman, Halil
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofAnnals Of The Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPentraxin-3en_US
dc.subjectFetuin-A
dc.subjectIL-6
dc.subjectInsulin
dc.subjectHOMA-IR Levels
dc.titleThe levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
1-s2.0-S1043466616300679-main.pdf
Boyut:
311.29 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu