The levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis
dc.authorid | 0000-0003-0411-9669 | en_US |
dc.authorid | 000000333957178 | |
dc.authorid | 0000-0001-5299-7250 | |
dc.authorid | 0000-0003-4178-8730 | |
dc.contributor.author | Tekeoğlu, İbrahim | |
dc.contributor.author | Kamanlı, Ayhan | |
dc.contributor.author | Sağ, Sinem | |
dc.contributor.author | Harman, Halil | |
dc.contributor.author | Altındiş, Mustafa | |
dc.date.accessioned | 2021-06-23T19:43:31Z | |
dc.date.available | 2021-06-23T19:43:31Z | |
dc.date.issued | 2016 | |
dc.department | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.description | Annual European Congress of Rheumatology (EULAR) -- JUN 08-11, 2016 -- London, ENGLAND | en_US |
dc.description.abstract | Objective: The aim of this study was to investigate the relationship between disease severity and bio- chemical parameters such as pentraxin-3, fetuin-A, IL-6, insulin and HOMA-IR levels in patients with rheumatoid arthritis. Methods: This study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were measured. Also, HOMA-IR values were calculated. Disease activity was assessed with Disease Activity Score (DAS28). To evaluate quality of life, the Health Assessment Questionnaire disability index was applied. Results: The serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were found to be higher than control subjects (p values = 0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively). A positive cor- relation was evident between the DAS 28 score and IL6 levels (r = 0.263, p = 0.045). We found no corre- lation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p < 0.05). Fetuin A levels were positively correlated with cumulative steroid dose (r = 0.382, p = 0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r = 0.437, p = 0.032). Conclusion: Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA. | en_US |
dc.identifier.doi | 10.1136/annrheumdis-2016-eular.1744 | |
dc.identifier.endpage | 196 | en_US |
dc.identifier.issn | 0003-4967 | |
dc.identifier.issn | 1468-2060 | |
dc.identifier.startpage | 196 | en_US |
dc.identifier.uri | https://doi.org/10.1136/annrheumdis-2016-eular.1744 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/8796 | |
dc.identifier.volume | 75 | en_US |
dc.identifier.wos | WOS:000401523101033 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.institutionauthor | Harman, Halil | |
dc.language.iso | en | en_US |
dc.publisher | Bmj Publishing Group | en_US |
dc.relation.ispartof | Annals Of The Rheumatic Diseases | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pentraxin-3 | en_US |
dc.subject | Fetuin-A | |
dc.subject | IL-6 | |
dc.subject | Insulin | |
dc.subject | HOMA-IR Levels | |
dc.title | The levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis | en_US |
dc.type | Article | en_US |
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