The levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmj Publishing Group
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study was to investigate the relationship between disease severity and bio-
chemical parameters such as pentraxin-3, fetuin-A, IL-6, insulin and HOMA-IR levels in patients with
rheumatoid arthritis.
Methods: This study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were measured. Also, HOMA-IR values were calculated. Disease activity
was assessed with Disease Activity Score (DAS28). To evaluate quality of life, the Health Assessment
Questionnaire disability index was applied.
Results: The serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were found to be
higher than control subjects (p values = 0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively). A positive cor-
relation was evident between the DAS 28 score and IL6 levels (r = 0.263, p = 0.045). We found no corre-
lation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p < 0.05). Fetuin A levels were positively correlated with cumulative steroid dose (r = 0.382, p = 0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r = 0.437, p = 0.032).
Conclusion: Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA.
Açıklama
Annual European Congress of Rheumatology (EULAR) -- JUN 08-11, 2016 -- London, ENGLAND
Anahtar Kelimeler
Pentraxin-3, Fetuin-A, IL-6, Insulin, HOMA-IR Levels
Kaynak
Annals Of The Rheumatic Diseases
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
75
