Postadölesan akneli kadınlarda serum büyüme hormonu ve insülin-benzeri büyüme faktörü-1 düzeyleri
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Akne vulgaris pilosebase ünitenin inflamatuvar bir hastalığıdır. Genellikle ergenlik döneminde başlar ancak yetişkin dönemine de uzayabilir. Çalışmamızda diğer hormonal parametreleri normal olan kadın hastalarda postadölesan akne etyopatogenezinde rol alabilecek İnsülin-benzeri büyüme faktörü (IGF) -1 ve Büyüme hormonu (GH) değerlerini araştırarak lezyonların türüyle bağlantılısını incelemeyi amaçladık. Gereç ve Yöntem: Çalışma Eylül 2005 ile Temmuz 2006 tarihleri arasında polikliniğimize postadölesan akne şikayeti ile başvuran diğer hormonal değerleri normal 30 kadın hasta ve yaşa göre eşleştirilmiş 25 sağlıklı kadından oluşan gönüllü kontrol grubu ile gerçekleştirildi. IGF-1 ve GH değerleri solid faz yarışmalı kemiluminesans yöntem ile çalışıldı. Bulgular: Yaş dağılımı çalışma grupları için benzerdi (p=0,726). IGF-1 düzeyleri hastalarda 336,5±112,88 ng/ml, kontrol grubunda 194±31,32 ng/ml olup istatistiksel olarak anlamlı yükseklik tespit edildi (p=0,000). GH düzeyleri hastalarda 3,16±4,35 µIU/ml, kontrol grubunda 1,15±1,21 µIU/ml olup istatistiksel olarak anlamlı yükseklik tespit edilmedi (p=0,03). Nodül varlığında IGF-1 düzeyi (p=0,015), kist varlığında ise GH düzeyi sınırda anlamlı (p=0,005) olarak tespit edildi. Sonuç: Çalışmamız, GH ve IGF-1’in özellikle postadölesan kadın hastalarda akne etyopatogenezindeki etkili olduğu yönündeki hipotezi desteklemektedir. Ancak çalışmamızın adölesan ve postadölesan kadın hastaları içeren iki ayrı grupta akne şiddetinin de belirlendiği kontrollü çalışmalarla desteklenmesi gerektiğini düşünüyoruz.
Background and Design: Acne vulgaris is an inflammatory disease of pilosebaceous unit. It usually starts after puberty but may continue into adulthood. We studied Growth hormone (GH) and insulin-like growth factor (IGF)-1 levels in women patients with acne vulgaris in whom all other hormon levels were normal. We aimed to show any relation of the acne vulgaris lesion type and GH and IGF-1 levels. Material and Method: The study conducted on the postadolesance period woman patients applying to out patient dermatology department with complaint of acne symptoms between Semtember 2005 and July 2006. All other hormonal parameters were normal in patients. 25 healthy similar age women were accepted as control. IGF-I and GH were quantified by solid-phase competitive chemiluminescence assays. Results: There was no difference according to age between the groups (p=0.726). The mean IGF-1 level was 336.5±112.88 ng/ml in patients and 194±31.32 ng/ml in control; the difference was significantly important (p=0.000). The mean GH level was 3.16±4.35 µIU/ml in patients and 1.15±1.21 µIU/ml in control; and the diffrence was not found as important (p=0.03). IGF-1 level was significantly important in patients with noduler involvement (p=0.015), and GH level was also significantly important in patients with cystic involvement (p=0.05). Conclusion: We supported the hypothesis that GH and IGF-1 levels were important in postadolasence period women patients with acne vulgaris. We recommend new studies comparing GH and IGF-1 levels in adolesence and postadolesence period women patients in order to support the role of these hormones in pathogenesis of acne vulgaris.
Background and Design: Acne vulgaris is an inflammatory disease of pilosebaceous unit. It usually starts after puberty but may continue into adulthood. We studied Growth hormone (GH) and insulin-like growth factor (IGF)-1 levels in women patients with acne vulgaris in whom all other hormon levels were normal. We aimed to show any relation of the acne vulgaris lesion type and GH and IGF-1 levels. Material and Method: The study conducted on the postadolesance period woman patients applying to out patient dermatology department with complaint of acne symptoms between Semtember 2005 and July 2006. All other hormonal parameters were normal in patients. 25 healthy similar age women were accepted as control. IGF-I and GH were quantified by solid-phase competitive chemiluminescence assays. Results: There was no difference according to age between the groups (p=0.726). The mean IGF-1 level was 336.5±112.88 ng/ml in patients and 194±31.32 ng/ml in control; the difference was significantly important (p=0.000). The mean GH level was 3.16±4.35 µIU/ml in patients and 1.15±1.21 µIU/ml in control; and the diffrence was not found as important (p=0.03). IGF-1 level was significantly important in patients with noduler involvement (p=0.015), and GH level was also significantly important in patients with cystic involvement (p=0.05). Conclusion: We supported the hypothesis that GH and IGF-1 levels were important in postadolasence period women patients with acne vulgaris. We recommend new studies comparing GH and IGF-1 levels in adolesence and postadolesence period women patients in order to support the role of these hormones in pathogenesis of acne vulgaris.
Açıklama
Anahtar Kelimeler
Akne, Postadölesan, Büyüme Hormonu, İnsülin-Benzeri Büyüme Faktörü-1, Acne, Postadolescence, Growth Hormone, Insulin-Like Growth Factor -1
Kaynak
Türkderm-Deri Hastalıkları ve Frengi Arşivi
Turkderm-Turkish Archives of Dermatology and Venereology
Turkderm-Turkish Archives of Dermatology and Venereology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
44
Sayı
2
