Melatonin metabolites protect human retinal pigment epithelial cells from death caused by oxidative stress
dc.authorid | 0000-0001-7830-8214 | en_US |
dc.authorid | 0000-0003-2940-3172 | en_US |
dc.authorid | 0000-0002-0270-9350 | en_US |
dc.contributor.author | Uras, Ebru | |
dc.contributor.author | Kılıçaslan, Derya | |
dc.contributor.author | Kurt, Akif Hakan | |
dc.contributor.author | Allı, Bilge | |
dc.contributor.author | Doğaner, Adem | |
dc.date.accessioned | 2023-06-23T06:54:41Z | |
dc.date.available | 2023-06-23T06:54:41Z | |
dc.date.issued | 2021 | en_US |
dc.department | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.description | Kahramanmaras Sutcu Imam University(Kahramanmaras Sutcu Imam University) | en_US |
dc.description.abstract | This study was aimed to determine the efficacy of 6-hydroxy melatonin and N-acetyl serotoninin protecting human retinal pigment epithelial cells from death brought about by oxidative-stress. The ARPE-19 cells (one of the retinal pigment epithelial cell lines) were used as the test cell culture. Following the application of 500 mu M H2O2, ARPE-19 cell line culture was incubated for 20 h to induce oxidative stress damage. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate the oxidative injury to ARPE-19 cells caused by H2O2 and the effectiveness of 6-hydroxy melatonin and N-acetyl serotonin application in preventing this damage. The results indicated that 6-hydroxy melatonin and N-acetyl serotonin exhibited a therapeutic effect on cells damaged by exposure to oxidative stress. It was concluded that these melatonin metabolites might be useful in treating many retinal conditions linked to the oxidative stress-induced damage. In addition, this study proposed a new idea for developing chemical approaches to the design and synthesis/semisynthesis of new drugs. | en_US |
dc.description.sponsorship | Kahramanmaras Sutcu Imam University | en_US |
dc.identifier.citation | Ebru, U., Derya, K., Hakan, K. A., Bilge, A., & Adem, D. (2021). Melatonin Metabolites Protect Human Retinal Pigment Epithelial Cells from Death Caused by Oxidative Stress. Pharmaceutical Chemistry Journal, 55, 762-768. | en_US |
dc.identifier.doi | 10.1007/s11094-021-02490-1 | |
dc.identifier.endpage | 768 | en_US |
dc.identifier.issn | 0091-150X | |
dc.identifier.issn | 1573-9031 | |
dc.identifier.issue | 8 | en_US |
dc.identifier.scopus | 2-s2.0-85119283267 | en_US |
dc.identifier.scopusquality | Q4 | en_US |
dc.identifier.startpage | 762 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1007/s11094-021-02490-1 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/11190 | |
dc.identifier.volume | 55 | en_US |
dc.identifier.wos | WOS:000720203300004 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.institutionauthor | Kurt, Akif Hakan | |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Pharmaceutical Chemistry Journal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 6-Hydroxy Melatonin | en_US |
dc.subject | N-Acetyl Serotonin | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Gamma-Aminobutyric-Acid | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Damage | en_US |
dc.title | Melatonin metabolites protect human retinal pigment epithelial cells from death caused by oxidative stress | en_US |
dc.type | Article | en_US |