Melatonin metabolites protect human retinal pigment epithelial cells from death caused by oxidative stress

dc.authorid0000-0001-7830-8214en_US
dc.authorid0000-0003-2940-3172en_US
dc.authorid0000-0002-0270-9350en_US
dc.contributor.authorUras, Ebru
dc.contributor.authorKılıçaslan, Derya
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorAllı, Bilge
dc.contributor.authorDoğaner, Adem
dc.date.accessioned2023-06-23T06:54:41Z
dc.date.available2023-06-23T06:54:41Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKahramanmaras Sutcu Imam University(Kahramanmaras Sutcu Imam University)en_US
dc.description.abstractThis study was aimed to determine the efficacy of 6-hydroxy melatonin and N-acetyl serotoninin protecting human retinal pigment epithelial cells from death brought about by oxidative-stress. The ARPE-19 cells (one of the retinal pigment epithelial cell lines) were used as the test cell culture. Following the application of 500 mu M H2O2, ARPE-19 cell line culture was incubated for 20 h to induce oxidative stress damage. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate the oxidative injury to ARPE-19 cells caused by H2O2 and the effectiveness of 6-hydroxy melatonin and N-acetyl serotonin application in preventing this damage. The results indicated that 6-hydroxy melatonin and N-acetyl serotonin exhibited a therapeutic effect on cells damaged by exposure to oxidative stress. It was concluded that these melatonin metabolites might be useful in treating many retinal conditions linked to the oxidative stress-induced damage. In addition, this study proposed a new idea for developing chemical approaches to the design and synthesis/semisynthesis of new drugs.en_US
dc.description.sponsorshipKahramanmaras Sutcu Imam Universityen_US
dc.identifier.citationEbru, U., Derya, K., Hakan, K. A., Bilge, A., & Adem, D. (2021). Melatonin Metabolites Protect Human Retinal Pigment Epithelial Cells from Death Caused by Oxidative Stress. Pharmaceutical Chemistry Journal, 55, 762-768.en_US
dc.identifier.doi10.1007/s11094-021-02490-1
dc.identifier.endpage768en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85119283267en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage762en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11094-021-02490-1
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11190
dc.identifier.volume55en_US
dc.identifier.wosWOS:000720203300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKurt, Akif Hakan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject6-Hydroxy Melatoninen_US
dc.subjectN-Acetyl Serotoninen_US
dc.subjectOxidative Stressen_US
dc.subjectGamma-Aminobutyric-Aciden_US
dc.subjectAntioxidanten_US
dc.subjectDamageen_US
dc.titleMelatonin metabolites protect human retinal pigment epithelial cells from death caused by oxidative stressen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
ebru-uras.pdf
Boyut:
1.29 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: