Investigation of the relationship between trefoil factor family peptides and sinonasal inflammation

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dc.authorid0000-0002-8993-8008en_US
dc.authorid0000-0002-4646-7250en_US
dc.authorid0000-0001-6006-0492en_US
dc.authorid0000-0002-6553-4500en_US
dc.contributor.authorSeyhan, Sinan
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorŞanal, Serap Köybaşı
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.date.accessioned2023-08-09T07:48:19Z
dc.date.available2023-08-09T07:48:19Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionThis work was supported by the Scientific Research Projects Coordinatorship of Bolu Abant Izzet Baysal University (Project Number: 2015.08.16.887).en_US
dc.description.abstractThe trefoil factor family (TFF) is a relatively new family of peptides. In some studies, an association between trefoil factors and inflammatory diseases of the nasal and paranasal sinuses has been suggested. However, it is still not clear whether there is a relationship between trefoil peptides and inflammation of the respiratory tract. The aims of this study are to determine the presence of TFF1, TFF2, and TFF3 in the nasal mucosa and investigate their relationships with inflammation by using rat models of various sinonasal inflammations. Nasal tampon, lipopolysaccharide, and ovalbumin were used to generate rat models of sinonasal inflammation, i.e., rhinosinusitis and allergic rhinitis. The study was conducted on seventy rats in seven groups, each with ten rats: four groups with rhinosinusitis, two groups with allergic rhinitis, and a control group. Histological evaluation of sinonasal mucosa from all rats was performed, and Trefoil factors were investigated using immunohistochemical methods. All three TFF peptides were detected in rat nasal mucosa by histological evaluation. No significant differences in the trefoil factor scores were observed among the study groups. A significant correlation between the TFF1 and TFF3 scores and loss of cilia was identified (p < 0.05). In conclusion, no direct relationship between sinonasal inflammation and TFF scores was observed. However, a possible association between the TFF and epithelial damage or regeneration in sinonasal inflammation can be suggested based on the correlation observed between the TFF1 and TFF3 scores and scores of cilia loss.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Bolu Abant Izzet Baysal University [2015.08.16.887]en_US
dc.identifier.citationSeyhan, S., Bicer, Y. O., Koybasi Sanal, S., & Astarci, H. M. (2023). Investigation of the Relationship Between Trefoil Factor Family Peptides and Sinonasal Inflammation. Indian Journal of Otolaryngology and Head & Neck Surgery, 75(Suppl 1), 1033-1040.en_US
dc.identifier.doi10.1007/s12070-023-03589-5
dc.identifier.endpage1040en_US
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issueSUPPL 1en_US
dc.identifier.pmid37206788en_US
dc.identifier.scopus2-s2.0-85148900439en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1033en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s12070-023-03589-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11462
dc.identifier.volume75en_US
dc.identifier.wosWOS:000939370200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBiçer, Yusuf Özgür
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectRhinosinusitisen_US
dc.subjectTrefoil Factoren_US
dc.subjectSpasmolytic Polypeptideen_US
dc.subjectChronic Rhinosinusitisen_US
dc.subjectExperimental Colitisen_US
dc.titleInvestigation of the relationship between trefoil factor family peptides and sinonasal inflammationen_US
dc.typeArticleen_US

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