Erythropoietin stimulates wound healing and angiogenesis in mice

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dc.authorid0000000215019324
dc.contributor.authorSayan, Hale
dc.contributor.authorÖzacmak, V. Haktan
dc.contributor.authorGüven, Aysel
dc.contributor.authorAktaş, R. Gülhan R.G.
dc.contributor.authorÖzacmak I. Diler I.D.
dc.date.accessioned2021-06-23T18:54:17Z
dc.date.available2021-06-23T18:54:17Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractErythropoietin exerts hematopoietic effects by stimulating proliferation of early erythroid precursors. Nonhematopoietic effects of erythropoietin have also been shown. It may act as a new angiogenic factor in wound healing. This study aimed to investigate the effect of systemic administration of recombinant human erythropoietin on wound healing in mice. Dorsal incisional wounds were performed in mice, which were then divided into two groups; a group treated for 7 days with recombinant human erythropoietin, and a control group. Sacrificing animals on day 7, the wound tissues were collected for analysis of wound breaking strength, malondialdehyde, a marker of lipid peroxidation, hydroxyproline, an index of reparative collagen deposition, reduced glutathione levels, and for histological evaluation. The immunohistochemical determination of vascular endothelial growth factor (VEGF) which is believed to be the most prevalent angiogenic factor throughout the skin repair process, was also studied. The treatment significantly increased wound breaking strength by decreasing malondialdehyde and increasing hydroxyproline levels on day 7 after wounding. No statistically meaningful change was observed in reduced glutathione content. VEGF was immunostained significantly more on wound tissue of treated animals compared to the control group. Recombinant human erythropoietin treatment may be effective in wound healing due to inhibition of lipid peroxidation, deposition of collagen, and VEGF expression in wound area. Copyright © Taylor & Francis Group, LLC.en_US
dc.identifier.doi10.1080/08941930600674694
dc.identifier.endpage173en_US
dc.identifier.issn0894-1939
dc.identifier.issue3en_US
dc.identifier.pmid16809226en_US
dc.identifier.scopus2-s2.0-33646498728en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.1080/08941930600674694
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4355
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüven, Aysel
dc.language.isoenen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreaking Strengthen_US
dc.subjectErythropoietinen_US
dc.subjectLipid Peroxidationen_US
dc.subjectVEGFen_US
dc.subjectWound healingen_US
dc.titleErythropoietin stimulates wound healing and angiogenesis in miceen_US
dc.typeArticleen_US

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