THYROID-RELATED FACTORS THAT INFLUENCE PREOPERATIVE LOCALIZATION OF PARATHYROID ADENOMAS

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dc.contributor.authorIsik, Serhat
dc.contributor.authorAkbaba, Gulhan
dc.contributor.authorBerker, Dilek
dc.contributor.authorTutuncu, Yasemin Ates
dc.contributor.authorOzuguz, Ufuk
dc.contributor.authorAydin, Yusuf
dc.contributor.authorPeksoy, Irfan
dc.date.accessioned2024-09-25T20:01:40Z
dc.date.available2024-09-25T20:01:40Z
dc.date.issued2012
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: To evaluate the effect that thyroid-related factors have on the preoperative localization of parathyroid adenomas. Methods: This retrospective study included adult patients who were referred for further evaluation of primary hyperparathyroidism between December 2005 and October 2009 at a teaching and research hospital in Turkey. High-frequency ultrasonography and sestamibi scintigraphy (MIBI) were performed in all patients. Surgical procedure involved focal or bilateral exploration on the basis of concordant or discordant imaging studies. Selection of patients for minimally invasive parathyroidectomy was made based on the presence or absence of a single parathyroid adenoma detected by both ultrasonography and MIBI scan. Patients with negative or discordant imaging studies and a concomitant thyroid nodule underwent bilateral neck exploration. Results: Two hundred and forty-eight patients with primary hyperparathyroidism who underwent parathyroidectomy were included in the study. Parathyroid gland abnormalities were successfully detected preoperatively by ultrasonography in 231 patients and by MIBI scan in 152 patients. When used together, ultrasonography and MIBI scan were unsuccessful in detecting an abnormality in 11 cases. MIBI scan visualized a lesion in 6 cases that remained undiagnosed by ultrasonography. Fifty-six of 85 patients with lesions detected by ultrasonography, but not by MIBI scan, had thyroid nodules. The frequency of thyroid nodules was higher in the 96 patients in whom a MIBI scan could visualize a parathyroid lesion than in the 152 patients in whom MIBI scan was successful (P = .004). No difference was observed regarding ipsilateral thyroid lobe involvement or nodule volume. Parathyroid adenomas were significantly smaller in patients with negative MIBI scans (P<.001). Conclusion: Our results suggest that ultrasonography is more sensitive than MIBI scan in the detection of parathyroid adenomas, particularly in the presence of small parathyroid adenomas or other thyroid related-factors. (Endocr Pract. 2012;18:26-33)en_US
dc.identifier.doi10.4158/EP11089.OR
dc.identifier.endpage33en_US
dc.identifier.issn1530-891X
dc.identifier.issue1en_US
dc.identifier.pmid21742606en_US
dc.identifier.scopus2-s2.0-84857546324en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.4158/EP11089.OR
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14252
dc.identifier.volume18en_US
dc.identifier.wosWOS:000300805400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGuler, Serdar
dc.language.isoenen_US
dc.publisherAmer Assoc Clinical Endocrinologistsen_US
dc.relation.ispartofEndocrine Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.titleTHYROID-RELATED FACTORS THAT INFLUENCE PREOPERATIVE LOCALIZATION OF PARATHYROID ADENOMASen_US
dc.typeArticleen_US

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