Lecithin-acrylamido-2-methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrier

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dc.authorid0000-0003-1956-4474en_US
dc.authorid0000-0003-2335-412Xen_US
dc.authorid0000-0003-4224-9309en_US
dc.authorid0000-0002-2909-689Xen_US
dc.authorid0000-0001-6054-8842
dc.contributor.authorMutlu, Esra Cansever
dc.contributor.authorBostan, Müge Sennaroğlu
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorKoçyiğit, Abdurrahim
dc.contributor.authorÖner, Ebru Toksoy
dc.date.accessioned2021-06-23T19:42:52Z
dc.date.available2021-06-23T19:42:52Z
dc.date.issued2016
dc.departmentBAİBÜ, Rektörlük, Bilimsel Endüstriyel ve Teknolojik Uygulama ve Araştırma Merkezi
dc.description.abstractIn this study, a novel paclitaxel (PTX) loaded and a crosslinked solid phospholipid nanoparticles (SLN-PTX) with negative surface charge was prepared by UV polymerization for drug delivery. Capping of positive charge of zwitterionic lecithin with negative charge of sodium 2-acrylamido-2-methyl-1-propanesulfonate (AMPS-Na) through cation exchange interaction produced a lecithin-AMPS (L-AMPS) complex. The amphiphilic and negative charged lipid complex was emulsified in the presence of emulsifier, paclitaxel, initiator, and methacrylated poly epsilon-caprolacton-diol (PCL-MAC) as a spacer. The colloidal system was subjected to UV-irradiation to obtain crosslinked nanoparticles. Completion of the UV-polymerization was monitored with differential scanning calorimetry (DSC), which indicated the disappearance of exothermic peaks of vinyl groups. The nanoparticle system, having an average size of 200 nm, exhibited high drug encapsulation (96%) with negatively charged surface (zeta potential had an average of -70 mV). PTX release profiles of the crosslinked and uncrosslinked SLN-PTXs were studied and their pharmacological properties were compared. The crosslinked nanoparticles exhibited more controlled release behavior with longer release time compared to the uncrosslinked ones. In vitro cytotoxicity test was conducted on MCF-7 human breast adenocarcinoma cell line, which indicated that the crosslinked SLN-PTXs have a potential therapeutic effect for breast cancer treatments. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44105.en_US
dc.identifier.doi10.1002/app.44105
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue42en_US
dc.identifier.scopus2-s2.0-84982803953en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.44105
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8628
dc.identifier.volume133en_US
dc.identifier.wosWOS:000380723800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorMutlu, Esra Cansever
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomaterialsen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectPhotopolymerizationen_US
dc.titleLecithin-acrylamido-2-methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrieren_US
dc.typeArticleen_US

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