Estradiol treatment ameliorates acetic acid-induced gastric and colonie injuries in rats

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dc.authorid0000-0001-6990-185X
dc.contributor.authorGünal, Ömer
dc.contributor.authorOktar, Berna K.
dc.contributor.authorÖzçınar, Emine
dc.contributor.authorSungur, Mustafa
dc.contributor.authorArbak, Serap
dc.date.accessioned2021-06-23T18:54:41Z
dc.date.available2021-06-23T18:54:41Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTo evaluate the role of estrogen treatment on the healing of acetic acid-induced gastric or colonic injury, rats were given 17? estradiol benzoate (0.001, 0.1, and 10 mg/kg) or vehicle for 7 days (following the induction of ulcer) or 4 days (following the induction of colitis) until they were decapitated. Food intake and fecal output were decreased by estradiol treatment but gastric emptying rate was not changed. Estradiol (10 mg/kg) reduced gastric ulcer index and colonic damage score compared to vehicle-treated groups. SEM and light microscopy demonstrated a significant reduction in the severity of ulcers and colitis by estradiol treatment. Gastric microscopic score was not changed by estradiol treatment, whereas in the colonic tissue score was significantly reduced. Elevated gastric MPO levels were reduced in gastric but not in colonic tissues as compared with corresponding vehicle groups. In conclusion, exogenous estradiol treatment at pharmacological doses improves the healing of both gastric and colonic injury induced by acetic acid in rats.en_US
dc.identifier.doi10.1023/B:IFLA.0000006703.53427.da
dc.identifier.endpage359en_US
dc.identifier.issn0360-3997
dc.identifier.issue6en_US
dc.identifier.pmid14760943en_US
dc.identifier.scopus2-s2.0-18244419816en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.1023/B:IFLA.0000006703.53427.da
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4537
dc.identifier.volume27en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünal, Ömer
dc.language.isoenen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetic aciden_US
dc.subjectEstradiolen_US
dc.subjectExperimental Colitisen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectUlcer Indexen_US
dc.titleEstradiol treatment ameliorates acetic acid-induced gastric and colonie injuries in ratsen_US
dc.typeArticleen_US

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