The effect of L-carnitine on wound healing by secondary intention in an animal model

dc.authorid0000-0001-8999-3237en_US
dc.authorid0000-0001-6006-0492
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorYılmaz, Taner
dc.date.accessioned2021-06-23T19:18:33Z
dc.date.available2021-06-23T19:18:33Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: L-carnitine [(CH3)(3)-N-CH2-CHOH-CH2-COC-] is an amino acid derivative found in high energy demanding tissues. It plays an active role under low oxygen conditions. The authors studied the effect of L-carnitine on wound healing by secondary intention on full-thickness surgical skin defects in an animal model. Materials and Methods: Twenty-two Sprague-Dawley rats were divided into 2 groups. A 4-cm diameter circular full-thickness surgical skin defect was created on the dorsum of each rat and was left to heal by secondary intention. L-carnitine was given intraperitoneally at a dose of 100mg/kg once daily to the study group for 10 days. The control group was injected intraperitoneally with saline (0.09% NaCl) only. On the 11th day, the skin defects were traced on a transparent sheet, and the unhealed areas were measured using planimetry. Results: The areas of skin defects measured at the end of the study were not significantly different between the 2 groups (p > 0.05). On the 11th day, the median of the defect area of the study group was 2.7cm(2), whereas that of the control group was 3.4cm(2). Conclusion: Although there was a tendency toward faster healing in the group receiving the drug, L-carnitine was not shown to significantly promote wound healing by secondary intention in an animal model. Further studies using different models, dosages, and durations of treatment are necessary to elucidate any possible effect.en_US
dc.identifier.endpage66en_US
dc.identifier.issn1044-7946
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-17444385966en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5757
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-17444385966&partnerID=40&md5=938102496482bababc43b376948643a8
dc.identifier.volume17en_US
dc.identifier.wosWOS:000228052300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKöybaşı, Serap
dc.language.isoenen_US
dc.publisherH M P Communicationsen_US
dc.relation.ispartofWounds-A Compendium Of Clinical Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-Carnitineen_US
dc.subjectWound Healing
dc.subjectSecondary Intention
dc.subjectAnimal Model
dc.titleThe effect of L-carnitine on wound healing by secondary intention in an animal modelen_US
dc.typeArticleen_US

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