Drug interaction between ivermectin and etomidate: Investigation on the effect of ivermectin on etomidate anaesthesia

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dc.authorid0000-0001-9865-1685
dc.contributor.authorYücel, Ufuk Mercan
dc.contributor.authorÖner, Ahmet Cihat
dc.contributor.authorTürel, İdris
dc.contributor.authorYılmaz, Orhan
dc.date.accessioned2021-06-23T19:53:56Z
dc.date.available2021-06-23T19:53:56Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe present study aims to determine the effect of ivermectin on the duration of anaesthesia performed with etomidate and to find out if there are any interactions between these two drugs at the central nervous system level. For this purpose, 25 Sprague-Dawley female rats were divided into 5 groups with 5 rats in each group. Group I received only subcutaneous saline at a dosage of 0.1 ml/100 g bw. Group II received the intraperitoneal injection of propylene glycol at a dosage of 1 mL/100 g bw. Group III received the subcutaneously 0.2 mg/kg bw ivermectin. Two hours after these treatments, neuropharmacological tests (rotarod and open field) were performed. Also, Group IV received 20 mg/kg bw etomidate intraperitoneally. Group V received subcutaneously 0.2 mg/kg bw ivermectin and 2 hours after the ivermectin administration, 20 mg/kg bw etomidate was given intraperitoneally. In these two groups, anaesthesia was monitored and the sleep duration was calculated based on rectal reflexes. Once the animals were fully awake, neuropharmacological tests were performed. Ivermectin that was administered two hours before the etomidate anaesthesia prolonged etomidate sleeping duration strongly. Also, ivermectin increased motion and decreased motor coordination, in association with etomidate it potentiates CNS depression (with prolonged sleep duration and decreased motor coordination).en_US
dc.identifier.doi10.31925/farmacia.2020.5.21
dc.identifier.endpage931en_US
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85094607035en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage925en_US
dc.identifier.urihttps://doi.org/10.31925/farmacia.2020.5.21
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10342
dc.identifier.volume68en_US
dc.identifier.wosWOS:000583251900021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherSoc Stiinte Farmaceutice Romaniaen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIvermectinen_US
dc.subjectEtomidateen_US
dc.subjectAnaesthesia Durationen_US
dc.titleDrug interaction between ivermectin and etomidate: Investigation on the effect of ivermectin on etomidate anaesthesiaen_US
dc.typeArticleen_US

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