Antiepileptic effects of exenatide in penicillin induced acute epilepsy model in rats

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dc.authorid0000-0002-5788-5298en_US
dc.authorid0000-0003-3279-1524en_US
dc.contributor.authorYıldız, Ayşegül
dc.contributor.authorKocacan, Süleyman Emre
dc.contributor.authorHim, Aydın
dc.date.accessioned2024-03-14T12:54:22Z
dc.date.available2024-03-14T12:54:22Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Lisansüstü Eğitim Enstitüsü, Sağlık Bilimleri, Fizyoloji Ana Bilim Dalıen_US
dc.descriptionThe present study was financially supported by a grant from Ondokuz Mayis University (PYO.TIP.1904.17.009) .en_US
dc.description.abstractGlucagon-like peptide-1 receptors are widely expressed in the brain and its association with nitric oxide is suggestive of its role in epilepsy. In this study, we investigated the effects of exenatide, a glucagon-like peptide-1 receptor agonist, on the epileptiform activity induced by penicillin injection. The study used 72 male Wistar albino rats in 9 groups. All groups except the last group which received only exenatide, received intracortical penicillin injection to induce epileptiform activity. Exenatide was intraperitoneally injected in II-IV groups, at doses of 50, 100, 200 & mu;g/kg, respectively. Sodium nitroprusside (SNP) and Nco-nitro-L-arginine methyl ester (L-NAME) were injected to the V-VIII groups either alone or with exenatide. Electrocorticography was recorded for 3 h. While administration of 200 & mu;g/kg exenatide reduced the frequency of epileptiform activity, 50 and 100 & mu;g/kg doses of exenatide were not effective. When the effective dose of exenatide and the SNP were injected together the spike frequency decreased significantly. When the effective dose of exenatide was given with L-NAME spike frequency significantly decreased only between 90 and 110 min. There was no statistically significant difference in terms of latency and amplitude between the experimental groups. Exenatide had an anticonvulsant effect in penicillin-induced acute epilepsy model which is possibly via nitric oxide and include another pathway since its effect was partially blocked by L-NAME and potentiated by SNP.en_US
dc.description.sponsorshipOndokuz Mayis University [PYO.TIP.1904.17.009]en_US
dc.identifier.citationYildiz, A., Kocacan, S. E., & Him, A. (2023). Antiepileptic effects of exenatide in penicillin induced acute epilepsy model in rats. Indian Journal of Experimental Biology (IJEB), 61(06), 417-423.en_US
dc.identifier.doi10.56042/ijeb.v61i06.1931
dc.identifier.endpage423en_US
dc.identifier.issn0975-1009
dc.identifier.issue6en_US
dc.identifier.startpage417en_US
dc.identifier.urihttp://dx.doi.org/10.56042/ijeb.v61i06.1931
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12092
dc.identifier.volume61en_US
dc.identifier.wosWOS:001021604600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorYıldız, Ayşegül
dc.institutionauthorHim, Aydın
dc.language.isoenen_US
dc.publisherThe National Institute of Science Communication and Information Resources (NISCAIR)en_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Electrocorticograhyen_US
dc.subjectGlucagon-Like Peptide (GLP)en_US
dc.subjectNitric Oxideen_US
dc.subjectInduced Epileptiform Activityen_US
dc.subjectGLP-1en_US
dc.subjectMechanismsen_US
dc.titleAntiepileptic effects of exenatide in penicillin induced acute epilepsy model in ratsen_US
dc.typeArticleen_US

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