Acute necrotizing encephalopathy of childhood: a single-center experience

dc.authoriduysal yazici, mutlu/0000-0001-7377-4718
dc.authoridOzkan, Mehbare/0000-0003-0896-8799
dc.authoridCeylan, Nesrin/0000-0001-5844-1261
dc.authoridOZDEMIR, Fatih Mehmet Akif/0000-0003-4820-1234
dc.contributor.authorAksoy, Erhan
dc.contributor.authorOztoprak, Ulku
dc.contributor.authorCelik, Halil
dc.contributor.authorOzdemir, Fatih Mehmet Akif
dc.contributor.authorOzkan, Mehpare
dc.contributor.authorKayalioglu, Hulya
dc.contributor.authorDanis, Aysegul
dc.date.accessioned2024-09-25T19:57:49Z
dc.date.available2024-09-25T19:57:49Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 +/- 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1-4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study.en_US
dc.identifier.doi10.3906/sag-2102-47
dc.identifier.endpage715en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid33754655en_US
dc.identifier.scopus2-s2.0-85105462251en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage706en_US
dc.identifier.trdizinid484017en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2102-47
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/484017
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13608
dc.identifier.volume51en_US
dc.identifier.wosWOS:000646281600041en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKucur, Ozge
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectFebrile illnessen_US
dc.subjectencephalopathyen_US
dc.subjectmultifocal brain lesionsen_US
dc.subjectseizure(s)en_US
dc.subjectchildhooden_US
dc.titleAcute necrotizing encephalopathy of childhood: a single-center experienceen_US
dc.typeArticleen_US

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