Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung

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dc.authorid0000-0002-6949-9191
dc.authorid0000-0001-8484-1146
dc.contributor.authorArınç, Emel
dc.contributor.authorArslan, Şevki
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorAdalı, Orhan
dc.date.accessioned2021-06-23T19:20:41Z
dc.date.available2021-06-23T19:20:41Z
dc.date.issued2007
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description7th Annual Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX) -- AUG 29-SEP 02, 2004 -- Vancouver, CANADAen_US
dc.description.abstractThere are limited number of studies regarding the influence of diabetes on the regulation of cytochrome P450s and associated drug metabolizing enzyme activities especially in extrahepatic tissues such as kidney. However, there is almost no such study in lung. Alloxan-induced diabetes did not change CYP2B4 expression as measured with immunoblot analysis and associated enzyme, benzphetamine N-demethylase, activity in rabbit kidney and lung. Induction of cytochrome P4502E1 by diabetes was identified by immunochemical detection on Western blots in the lung and kidney microsomes of rabbits. In parallel to CYP2EI induction, aniline 4-hydroxylase and p-nitrophenol hydroxylase activities were markedly increased in diabetic rabbit lung and kidney. CYP2B4 and CYP2E1 dependent drug metabolism did not show any tissue variation in diabetic rabbit. These findings are in contrast to those of rats, mice and hamster. The results of the present work, in combination with those of the previous work [Arinc, E., Arslan, S., Adali, O., 2005. Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver. Arch. Toxicol. 79, 427433], indicate the existence of species-dependent response of GYP-dependent drug metabolizing enzymes to diabetes. A procarcinogen and food contaminant, N-nitrosodimethylamine (NDMA), is converted to its carcinogenic form after it is activated with NDMA N-demethylase. In the current study, a statistically significant increase of liver, kidney and lung NDMA N-demethylase activity associated with CYP2E1 was shown in diabetic rabbit. Thus, it is expected that, the risk of nitrosamine induced carcinogenesis will be greater in liver, kidney and lung of the diabetic subjects. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInt Soc Study Xenobioten_US
dc.identifier.doi10.1016/j.fct.2006.07.026
dc.identifier.endpage118en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue1en_US
dc.identifier.pmid17034923en_US
dc.identifier.scopus2-s2.0-33751209799en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2006.07.026
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6152
dc.identifier.volume45en_US
dc.identifier.wosWOS:000243441300014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozcaarmutlu, Azra
dc.institutionauthorAdalı, Orhan
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood And Chemical Toxicologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectRabbit liveren_US
dc.subjectLungen_US
dc.subjectKidneyen_US
dc.subjectCYP2E1en_US
dc.subjectCYP2B4en_US
dc.subjectNDMAen_US
dc.subjectP-nitrophenolen_US
dc.subjectNDMA N-demethylaseen_US
dc.subjectP-nitrophenol hydroxylaseen_US
dc.subjectAniline 4-hydroxylaseen_US
dc.subjectCytochrome P450 reductaseen_US
dc.subjectBenzphetamine N-demethylaseen_US
dc.titleEffects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lungen_US
dc.typeConference Objecten_US

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