Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice

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dc.authorid0000-0003-2951-6038en_US
dc.authorid0000-0002-7151-9630en_US
dc.authorid0000-0002-6120-4790en_US
dc.contributor.authorMeck, Warren H.
dc.contributor.authorCheng, Ruey-Kuang
dc.contributor.authorMacDonald, Christopher J.
dc.contributor.authorGainetdinov, Raul R.
dc.contributor.authorCaron, Marc G.
dc.contributor.authorÇevik, Münire Özlem
dc.date.accessioned2021-06-23T19:33:53Z
dc.date.available2021-06-23T19:33:53Z
dc.date.issued2012
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.description.abstractThe dopamine transporter (DAT) is the major regulator of the spatial and temporal resolution of dopaminergic neurotransmission in the brain. Hyperdopaminergic mice with DAT gene deletions were evaluated for their ability to perform duration discriminations in the seconds-to-minutes range. DAT -/- mice were unable to demonstrate temporal control of behavior in either fixed-interval or peak-interval timing procedures, whereas DAT +/- mice were similar to DAT +/+ mice under normal conditions. Low to moderate-dose methamphetamine (MAP) challenges indicated that DAT +/- mice were less sensitive to the clock-speed enhancing effects of MAP compared with DAT +/+ mice. In contrast, DAT +/- mice were more vulnerable than DAT +/+ mice to the disruptive effects of MAP at high doses as revealed by the elevation of response rate in the righthand tail of the Gaussian-shaped timing functions. Moreover, this treatment made DAT +/- mice functionally equivalent to DAT -/- mice in terms of the loss of temporal control. Taken together, these results demonstrate the importance of dopaminergic control of interval timing in corticostriatal circuits and the potential link of timing dysfunctions to schizophrenia and drug abuse. This article is part of a Special Issue entitled 'Schizophrenia'. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.neuropharm.2011.01.042
dc.identifier.endpage1229en_US
dc.identifier.issn0028-3908
dc.identifier.issn1873-7064
dc.identifier.issue3en_US
dc.identifier.pmid21296093en_US
dc.identifier.startpage1221en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2011.01.042
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7256
dc.identifier.volume62en_US
dc.identifier.wosWOS:000300533800008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇevik, Münire Özlem
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNeuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTiming and Time Perceptionen_US
dc.subjectPsychiatric Dysfunctionen_US
dc.subjectSchizophreniaen_US
dc.subjectDopamineen_US
dc.subjectGlutamateen_US
dc.subjectCortico-Striatal Circuitsen_US
dc.titleGene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout miceen_US
dc.typeArticleen_US

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