Evaluation of retina and retinal nerve fiber layer thicknesses with vitamin b12 deficiency

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dc.authorid0000-0002-8249-2621
dc.authorid0000-0001-8616-832X
dc.authorid0000-0003-4468-3985
dc.authorid0000-0002-3053-2396
dc.authorid0000-0003-1018-925X
dc.contributor.authorDoğan, Ümit
dc.contributor.authorTürkoğlu, Şule Aydın
dc.contributor.authorUlaş, Fatih
dc.contributor.authorSoydan, Adem
dc.contributor.authorKaymaz, Abdulgani
dc.contributor.authorEroğlu, Tarık
dc.contributor.authorAğca, Sümeyra
dc.date.accessioned2021-06-23T19:43:04Z
dc.date.available2021-06-23T19:43:04Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractAim: We aimed to compare the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness of B12 vitamin deficiency patients with healthy controls using optical coherence tomography (OCT). Methods: Forty-six patients (27 females / 19 males) diagnosed with B12 vitamin deficiency and 46 healthy controls (26 females / 20 males) with similar age and sex were included in the study. RNFL thickness of global, superotemporal, temporal, inferotemporal, superonasal, nasal and inferonasal sectors and GCL thickness and volume measurements of central, superior, inferior, temporal, and nasal sectors were performed using Spectralis-OCT device in all cases. Results: The mean age of the patient group was 42.17±15.34 years, while that of the control group was 44.21±12.34 years (p=0.528). Mean serum vitamin B12 levels were measured as 163,47±19,80 pg/ml in the patient group and 311,80±76,30 pg/ml in the control group (p <0,01). There was no statistically significant difference between the global RNFL thicknesses of the two groups (p> 0,05). However, statistically non-significant thinning was observed in the superotemporal and global RNFL thickness of the group with B12 vitamin deficiency (p values are 0,140 and 0,171, respectively). There was also no statistically significant difference between GCL thicknesses and volumes of the two groups (p> 0.05). Conclusions: No significant reduction was observed in RNFL and GCL thicknesses of adult subjects with B12 vitamin deficiency compared with healthy controls. Keywords: Ganglion cell layer; optical coherence tomography; retinal nerve fiber layer; vitamin B12 deficiency.en_US
dc.identifier.endpage67en_US
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.startpage67en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8684
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000383578300177
dc.identifier.volume218en_US
dc.identifier.wosWOS:000383578300177en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorDoğan, Ümit
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorUlaş, Fatih
dc.institutionauthorEroğlu, Tarık
dc.institutionauthorAğca, Sümeyra
dc.institutionauthorSoydan, Adem
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Physiologicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin B12 Deficiencyen_US
dc.subjectRetina
dc.subjectRetinal Nerve Fiber Layer Thicknesses
dc.titleEvaluation of retina and retinal nerve fiber layer thicknesses with vitamin b12 deficiencyen_US
dc.typeConference Objecten_US

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