Very important histopathological factors in patients with resected non-small cell lung cancer: Necrosis and perineural invasion

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dc.authorid0000-0002-0549-9969en_US
dc.authorid0000000246001290
dc.authorid0000-0003-3229-830X
dc.contributor.authorKılıçgün, Hacıali
dc.contributor.authorTurna, Akif
dc.contributor.authorSayar, Adnan
dc.contributor.authorSolak, O.
dc.contributor.authorÜrer, N.
dc.date.accessioned2021-06-23T19:27:10Z
dc.date.available2021-06-23T19:27:10Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The current staging system provides an anatomical classification of lung tumors; its secondary purpose is to allow the prognostic stratification of patients into homogeneous groups after surgery. In this work, intratumoral perineural invasion, lymphatic and blood vessel invasion together with the necrosis content of the tumor exclusive of the non-small cell cancer staging system were studied. Methods: During a 4-year period, 152 patients operated for non-small cell lung cancer (NSCLC) at our hospital were analyzed. Mean age of patients was 55.7 +/- 10.1 years. Results: Overall 5-year survival was 42.2%. Mediastinal lymph node involvement, tumor size, incomplete resection, pneumonectomy, presence of necrosis and perineural invasion were significant prognosticators (p = 0.03, 0.04, 0.0001, 0.046, 0.0246, < 0.0001, respectively). Multivariate analysis revealed that N status, perineural invasion, and the presence of necrosis were independent prognostic factors (p = 0.006, p = 0.001, p = 0.001, respectively). Patients who had stage I tumor with necrosis and perineural invasion had a lower survival rate than those with stage IIIA tumor without these histopathological features (p = 0.04). The presence of these histopathological characteristics in stage IIIA patients was a sign of a poorer prognosis (p = 0.0001). Conclusions: Perineural invasion and the presence of necrosis independently indicated a dismal prognosis and their prognostic power is comparable to those of the TNM classification. These factors could be candidates for better survival stratification and the indicators of the need for adjuvant therapy in early stage lung cancer patients.en_US
dc.identifier.doi10.1055/s-0029-1186240
dc.identifier.endpage97en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue2en_US
dc.identifier.pmid20333571en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1055/s-0029-1186240
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6752
dc.identifier.volume58en_US
dc.identifier.wosWOS:000275888500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılıçgün, Hacıali
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThoracic Surgeryen_US
dc.subjectStagingen_US
dc.subjectHistopathological Factorsen_US
dc.subjectResectionen_US
dc.titleVery important histopathological factors in patients with resected non-small cell lung cancer: Necrosis and perineural invasionen_US
dc.typeArticleen_US

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