Inhibitory effect of organic acids on human neutrophil Myeloperoxidase's peroxidation, chlorination, and nitration activities

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dc.authorid0000-0002-2948-2635en_US
dc.contributor.authorSarkarati, Bahram
dc.date.accessioned2024-05-08T11:15:38Z
dc.date.available2024-05-08T11:15:38Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionThis work was supported by the Scientific Research Projects Department of Bolu Abant Izzet Baysal University (grant numbers 2019.31.01.1412). The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in writing of the report; or in the decision to submit report for publication.en_US
dc.description.abstractObjectives Myeloperoxidase from polymorphonuclear leukocytes is an important enzyme in oxidative metabolism and has a key role in tissue injuries in oxidative stress and inflammatory conditions. Therefore, its inhibitors have become the focus of studies on new drug development in recent years. The aim of the study was to determine the inhibitory effect of organic acids on the peroxidation, chlorination, and nitration activities of myeloperoxidase.Methods Seven organic acids naturally abundant in plants were tested. Different activities of myeloperoxidase were measured in the presence of various amounts of organic acids, and inhibition rates and kinetic parameters were determined for each organic acid separately.Results All the organic acids examined had inhibitory effects on the different activities of myeloperoxidase. Comparison of the IC50 values obtained for peroxidation, chlorination, and nitration activities showed that oxalic acid was the strongest inhibitor of myeloperoxidase activity, while citric acid and succinic acid were the weakest.Conclusions The results suggested that all the organic acids examined are inhibitors of myeloperoxidase. In particular, oxalic acid and fumaric acid are popular candidates for drug development research. More studies are needed to determine the in vivo effects of organic acids and their effects in the treatment of disease.en_US
dc.description.sponsorshipScientific Research Projects Department of Bolu Abant Izzet Baysal University [2019.31.01.1412]en_US
dc.identifier.citationSarkarati, B. (2023). Inhibitory effect of organic acids on human neutrophil myeloperoxidase’s peroxidation, chlorination, and nitration activities. Turkish Journal of Biochemistry, 48(5), 485-491.en_US
dc.identifier.doi10.1515/tjb-2022-0260
dc.identifier.endpage491en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85176452289en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage485en_US
dc.identifier.trdizinid1252373en_US
dc.identifier.urihttp://dx.doi.org/10.1515/tjb-2022-0260
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12134
dc.identifier.volume48en_US
dc.identifier.wosWOS:001033588100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorSarkarati, Bahram
dc.language.isoenen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.relation.ispartofTurkish Journal of Biochemistry - Türk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectNatural Productsen_US
dc.subjectInflammationen_US
dc.subjectOxidantsen_US
dc.titleInhibitory effect of organic acids on human neutrophil Myeloperoxidase's peroxidation, chlorination, and nitration activitiesen_US
dc.typeArticleen_US

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