Increased systemic inflammatory response with mast cell activation in elder children with cerebral palsy

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dc.authorid0000-0001-8140-9892en_US
dc.authorid0000-0002-1795-5677en_US
dc.authorid0000-0001-9261-2634en_US
dc.contributor.authorDemir, Cemalettin
dc.contributor.authorKılınç, Yasemin Baranoğlu
dc.contributor.authorKılınç, Erkan
dc.date.accessioned2023-12-18T12:47:37Z
dc.date.available2023-12-18T12:47:37Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Mehmet Tanrıkulu Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.descriptionThis study was supported by Bolu Abant Izzet Baysal University Scientific Research Fund (Grant-number: 2019.08.02.1415) .en_US
dc.description.abstractObjective: Increased systemic inflammatory response during intrauterine period or period before the age of 3 is associated with cerebral palsy (CP) pathogenesis; however, effects of inflammatory processes involving mast cell activation in elder children with CP remain unclear. We aimed to investigate the role of mast cells and proinflammatory cytokines in children with CP at 3-18 years of age. Methods: In this cross-sectional study, venous blood samples were obtained from 30 volunteers with CP and 26 healthy volunteers at 3-18 years of age. Plasma levels of proinflammatory cytokines (IL-1 beta, IL-6 and IL-9) and mast cell biomarkers (histamine and tryptase beta-2) were determined using ELISA. Results: IL-1 beta, IL-6 and histamine levels were higher in individuals with CP compared to healthy controls. Likewise, IL-1 beta, IL-6, IL-9 and histamine levels were higher in the female patients with CP compared to the male patients, and in the female patients in adolescence compared to the female patients in pre-adolescence. Conclusion: Our findings indicate that the increased inflammatory response contributes to the pathogenesis of the disease in children with CP who are older than 2 years of age. Moreover the increased inflammatory response is more effective in female patients than in male patients, suggesting that there may be a gender difference in CP. Additionally mast cell activation contributes to the exacerbation of systemic inflammatory response in children with CP at 3-18 years of age.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Fund [2019.08.02.1415]en_US
dc.identifier.citationDemir, C., KILINÇ, Y. B., & Kilinc, E. (2022). Increased Systemic Inflammatory Response with Mast Cell Activation In Elder Children With Cerebral Palsy. Clinical and Experimental Health Sciences, 12(2), 294-301.en_US
dc.identifier.doi10.33808/clinexphealthsci.983877
dc.identifier.endpage301en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage294en_US
dc.identifier.trdizinid532937en_US
dc.identifier.urihttp://dx.doi.org/10.33808/clinexphealthsci.983877
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11903
dc.identifier.volume12en_US
dc.identifier.wosWOS:000823273900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDemir, Cemalettin
dc.institutionauthorKılınç, Yasemin Baranoğlu
dc.institutionauthorKılınç, Erkan
dc.language.isoenen_US
dc.publisherMarmara University, Institute of Health Sciencesen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebral Palsyen_US
dc.subjectChildrenen_US
dc.subjectInflammationen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectNeonatal Cytokinesen_US
dc.subjectVentricular Repolarizationen_US
dc.titleIncreased systemic inflammatory response with mast cell activation in elder children with cerebral palsyen_US
dc.typeArticleen_US

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