Mean platelet volume increases in type 2 diabetes mellitus independent of HBA1C level

Aims: Diabetes mellitus is an important health problem worldwide and associated with subclinical inflammation. Several inflammatory markers have been studied in these conditions. Mean platelet volume and red cell distribution width are hemogram parameters that are suggested to be related with inflammation. We aimed to study hemogram parameters of type 2 diabetic patients, and compare to healthy subjects, retrospectively. Methods: We included patients with type 2 diabetes mellitus in this retrospective study. Healthy subjects admitted to our institution for a routine check-up were included as control group. Laboratory data such as, white blood cell count (WBC), hemoglobin (Hb), red cell distribution width (RDW), platelet count (PLT) and mean platelet volume (MPV) and concomitant HbA1c values of the participants recorded. Results: We could not found a significant difference in RDW levels between groups. On the other hand, MPV was significantly elevated in study group compared to control subjects. Conclusion: We suggest that MPV is associated with type 2 diabetes mellitus. Prospective studies with a larger cohort are necessity to define the relationship of MPV and the level of metabolic control.