Bicuspid aortic valve and severe aortic stenosis in a newborn exposed to carbamazapine during pregnancy

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dc.contributor.authorKarataş, Zehra
dc.contributor.authorKarataş, Ahmet
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorGöksügür, Sevil Bilir
dc.contributor.authorVaran, Birgül
dc.date.accessioned2021-06-23T18:33:05Z
dc.date.available2021-06-23T18:33:05Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe use of antiepileptic drugs increases the risk of major congenital malformations during pregnancy. Here, we report an infant who had a history of in-utero carbamazepine exposure and who was born with a cardiac malformation. The infant was born at 39 weeks of gestation vagi- nally to an epileptic mother who had been treated with carbamazepine throughout her pregnancy. He was referred due to cardiac murmur in the second week of his life. The mother had not received folic acid supplementation. Transthoracic echocardiography revealed bicuspid aortic valve, mild aortic stenosis, patent ductus arteriosus, patent foramen ovale and the renal ultrasound revealed mild left hydronephrosis. Follow-up echocardiography performed 14 weeks later showed increased severity of aortic stenosis and percutaneous balloon aortic valvuloplasty was performed. To our knowledge, there is only one case report in the literature mentioning the association of a bicuspid aortic valve and aortic stenosis with oxcarbazepine exposure, which is a structural derivative of carbamazepine. However, there are no reports for association with carbamazepine itself. Bicuspid aorta and aortic stenosis may be among the cardiac malformations that result from the teratogenic effect of carbamazepine.en_US
dc.identifier.endpage261en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84919761190en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage259en_US
dc.identifier.trdizinid163936en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRZek9UTTJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/2135
dc.identifier.volume15en_US
dc.identifier.wosWOS:000420676800013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKarataş, Zehra
dc.institutionauthorKarataş, Ahmet
dc.institutionauthorÖzlü, Tülay
dc.institutionauthorGöksügür, Sevil Bilir
dc.language.isoenen_US
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryOlgu Sunumu - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAortic Stenosis
dc.subjectBicuspid Aortic Valve
dc.subjectCarbamazepine
dc.subjectPregnancy
dc.titleBicuspid aortic valve and severe aortic stenosis in a newborn exposed to carbamazapine during pregnancyen_US
dc.typeCase Reporten_US

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