Genotype distribution of hepatitis C virus in the province of Gaziantep, a 10-year evaluation

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dc.authoridcirit, osman sezer/0000-0003-1064-3766
dc.contributor.authorCirit, Osman Sezer
dc.contributor.authorDemir, Yelda
dc.contributor.authorYildirim, Mehmet Sait
dc.contributor.authorAlpaslan, Buket
dc.contributor.authorAvcioglu, Fatma
dc.contributor.authorDogn, Yusuf
dc.contributor.authorAstam, Pinar
dc.date.accessioned2024-09-25T19:58:37Z
dc.date.available2024-09-25T19:58:37Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractHepatitis C virus (HCV) can cause both acute and chronic hepatitis infections. Gaziantep is located southeast part of Turkey and has a border with Syria. More than 400,000 Syrian refugees live in Gaziantep. The aim of this study was to evaluate distribution of HCV genotypes among Syrian patients and in people who inject drugs. Serum samples form 1,628 individuals (786 female, 842 male) which were sent to our laboratory for genotyping between January 2013 and December 2022, were analyzed retrospectively. Three different HCV genotyping assays (Qiagen, RTA and Abbott) were used during the 10-year study period. Out of the 1,628 patients, genotype 1 was detected in 51.5%, genotype 3 in 21.4%, genotype 4 in 20%, genotype 5 in 4.6%, genotype 2 in 1.3%. Mixed genotype was found in 20 patients. Of the patients, 1,143 were Turkish patients and among those patients genotype 1 (66.8%) was the most common genotype followed by genotype 3 (29%). Among Syrian patients (n 5 477), genotype 4 (64.2%) was predominant genotype followed by genotype 1 and genotype 5. Genotype 3 was detected in 277 (79.6%) prisoners. All of them were male and probably the main source of HCV infection was intravenous drug abuse. While genotypes 1 and 4 were common in females, genotypes 1 and 3 were common in males. In the future genotype 3 may become an increasing problem due to the persons who inject drugs. Less frequent genotypes such as 4 and 5 may become more frequent due to Syrian patients.en_US
dc.identifier.doi10.1556/030.2023.02137
dc.identifier.endpage352en_US
dc.identifier.issn1217-8950
dc.identifier.issn1588-2640
dc.identifier.issue4en_US
dc.identifier.pmid38063902en_US
dc.identifier.scopus2-s2.0-85179646598en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.1556/030.2023.02137
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13668
dc.identifier.volume70en_US
dc.identifier.wosWOS:001128133700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Microbiologica Et Immunologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjecthepatitis C virusen_US
dc.subjectgenotypeen_US
dc.subjectmigrationen_US
dc.subjectmolecular microbiologyen_US
dc.subjectpersons who inject drugsen_US
dc.titleGenotype distribution of hepatitis C virus in the province of Gaziantep, a 10-year evaluationen_US
dc.typeArticleen_US

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