Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?

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dc.authorid0000-0002-9854-7586en_US
dc.authorid0000-0002-9661-8344en_US
dc.authorid0000-0002-8270-7354en_US
dc.authorid0000-0002-1287-8166
dc.contributor.authorDeveci, Erdem
dc.contributor.authorKocacenk, Tuba
dc.contributor.authorŞahan, Ebru
dc.contributor.authorYılmaz, Onur
dc.contributor.authorÖztürk, Ahmet
dc.contributor.authorKırpınar, İsmet
dc.date.accessioned2021-06-23T19:50:43Z
dc.date.available2021-06-23T19:50:43Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Psoriasis is a chronic, inflammatory skin disease which has been linked to psychopathology. Oxidative stress and inflammation are associated with atherogenesis and neuronal stress thus, cognitive functions might be impaired in psoriasis patients. We aimed to compare psychiatric comorbidity, neurocognitive functions, oxidative stress and inflammatory cytokine levels in psoriasis patients with healthy controls, besides to evaluate the effect of oxidative stress and inflammation on comorbidity and cognitive functions in psoriasis patients. Methods: A total of 37 patients (11 male and 26 female) aged between 18 and 65 years with at least 5 years of education who applied to the Dermatology Outpatient Clinic of the study hospital between study period; diagnosed with psoriasis by physical examination and histopathological evaluation were included in the study. The control group was formed from healthy individuals working for the hospital. Sociodemographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Semantic Verbal Fluency Test (K-A-S), oktem Verbal Memory Processes Test, Auditory Consonant Trigram Test and Wisconsin Card Sorting Test were performed to all participants. In addition, blood samples of participants were analysed to assess total oxidant stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and proinflammatory cytokines TNF-alpha and IL-6 levels. Results: BDI and BAI scores, TOS, OSI, TNF-alpha and IL-6 levels of psoriasis patients were significantly higher than controls. Besides, the cognitive domains of learning, recall and verbal fluency in psoriasis patients were shown to be impaired. The increased levels of depression and anxiety in psoriasis did not significantly affect the serum TAS, TOS and OSI levels. Increased IL-6 and TNF-alpha levels were not significantly related to depression in patients with psoriasis. Conclusion: Psoriasis patients have higher risk factors than healthy controls for cognitive impairment, independent of depression, inflammation and oxidative stress levels.en_US
dc.identifier.doi10.1080/24750573.2019.1589176
dc.identifier.endpage695en_US
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85062991215en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage682en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2019.1589176
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9848
dc.identifier.volume29en_US
dc.identifier.wosWOS:000510621700030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKocacenk, Tuba
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPsychiatry And Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPsoriasisen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectOxidative Stressen_US
dc.subjectInflammationen_US
dc.titleOxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?en_US
dc.typeArticleen_US

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