Platelet distribution width and neutrophil-lymphocyte ratio in progression to preeclampsia and severe preeclampsia

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dc.authorid0000-0001-6163-6756
dc.authorid0000-0002 -0745-0907
dc.contributor.authorEkici, Mustafa Ayhan
dc.contributor.authorUral, Ülkü Mete
dc.date.accessioned2021-06-23T19:52:28Z
dc.date.available2021-06-23T19:52:28Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and aim: Preeclampsia is a multisystemic, hypertensive disorder without a well-known etiology, affecting 3-9% of pregnancies. The aim of this study is to demonstrate the roles of hematological markers at prediction of PE by a comparison between their levels prior and following the disorder and at determine the usefulness of them at deciding the severity of PE. Material and methods: This research is a retrospective and cross-sectional study performed between January 2012 and March 2018. SPSS (Statistical Package for Social Sciences) version 15.0 (SPSS Inc., USA) is used for statistical analysis.. Kolmogorov-Smirnov, Anova, Kruskal-Wallis, Paired Samples and Wilcoxon tests are used for interpreting data. Test results are assesed within 95% confidence interval and statistical significance is considered if p<0.05. Results: Two hundred and sixty nine pregnant women were recruited into our study. 115 women delivered with severe preeclampsia (SPE), 105 with mild preeclampsia (MPE) and 49 with gestational hypertension (GHT). After the progression to severe preeclampsia, MPV, RDW and PDW were found higher (p=0.005, p=0.0002, p=0.032). RDW is significantly elevated after diagnosis of MPE (p=0.006). After the diagnosis of SPE, MPE and GHT, MPV was higher in SPE subgroup with respect to MPE and GHT subgroups (respectively p=0.043, p=0.014). PDW and NLR were significantly lower in gestational hypertension patients which were evolving to preeclampsia (p=0.015, p=0.010). Conclusion: Lower PDW and NLR levels were found to be related with developing preeclampsia in GHT patients. As preeclamp-sia becomes severe, MPV levels increase and platelet counts decrease.en_US
dc.identifier.doi10.19193/0393-6384_2019_6_522
dc.identifier.endpage3322en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85074951051en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3317en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2019_6_522
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10155
dc.identifier.volume35en_US
dc.identifier.wosWOS:000496261400069en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUral, Ülkü Mete
dc.institutionauthorEkici, Mustafa Ayhan
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectMean Platelet Volume (MPV)en_US
dc.subjectPlatelet Distribution Width (PDW)en_US
dc.subjectRed Cell Distribution Width (RDW)en_US
dc.subjectNumbers of Thrombocytes(PC)en_US
dc.subjectNLR(Neutrophil Lymphocyte Ratio)en_US
dc.titlePlatelet distribution width and neutrophil-lymphocyte ratio in progression to preeclampsia and severe preeclampsiaen_US
dc.typeArticleen_US

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