Angiotensin converting enzyme as a predictor of extrathoracic involvement of sarcoidosis

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dc.authorid0000-0003-1110-6823
dc.authorid0000-0002-0891-0020
dc.authorid0000-0002-7162-2611
dc.contributor.authorYaşar, Zehra
dc.contributor.authorÖzgül, Mehmet Akif
dc.contributor.authorÇetinkaya, Erdoğan
dc.contributor.authorKarğı, Aysel
dc.contributor.authorGül, Şule
dc.contributor.authorTalay, Fahrettin
dc.date.accessioned2021-06-23T19:42:25Z
dc.date.available2021-06-23T19:42:25Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Sarcoidosis is a multisystem disease, with extrathoracic involvement occurring in 25-50% of patients. Multi-organ involvement is often associated with a more chronic and severe course. The value of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in diagnosing extrathoracic involvement in sarcoidosis has been demonstrated; however, because of the radiation dose and high cost, indications for its use must be well defined. Angiotensin-converting enzyme (ACE) is produced by active granuloma cells; thus, serum ACE (sACE) levels may reflect the total granuloma load. Objectives: In this retrospective study, we evaluated the diagnostic value of sACE in the detection of extrathoracic involvement in sarcoidosis. Methods: 43 patients with biopsy-proven sarcoidosis underwent FDG-PET/CT during the initial work up. Positive findings were classified as thoracic and/or extrathoracic. The diagnostic value of sACE was estimated using sensitivity, specificity, and area under the receiver operating characteristic curves (AUCs). Results: Of the 43 patients studied, 17 (39.7%) had extrathoracic involvement. In this group, sACE values were higher than in patients without extrathoracic involvement (331 vs. 150, p=0.002) and correlated positively with extrathoracic involvement (R:0.532 p=0.02). Receiver operator characteristic curve analysis revealed an AUC of 0.816 [95% confidence interval: 0.669-0.963, p=0.002], 70.6% sensitivity and 80% specificity at the sACE cut-off value. Conclusions: In sarcoidosis, extrathoracic involvement may be life threatening or indicative of poor outcome. sACE levels are easily determined and may predict extrathoracic involvement. In patients with sarcoidosis, sACE levels can be used to better define those who would benefit from FDG-PET/CT examination to detect extrathoracic involvement.en_US
dc.identifier.endpage324en_US
dc.identifier.issn1124-0490
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8478
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000376024800007
dc.identifier.volume32en_US
dc.identifier.wosWOS:000376024800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYaşar, Zehra
dc.institutionauthorTalay, Fahrettin
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofSarcoidosis Vasculitis And Diffuse Lung Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSarcoidosisen_US
dc.subjectACEen_US
dc.subjectExtrathoracic Involvementen_US
dc.titleAngiotensin converting enzyme as a predictor of extrathoracic involvement of sarcoidosisen_US
dc.typeArticleen_US

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