Aldrin epoxidation in flathead Mullet (Mugil cephalus) : possible involvement of CYP1A and CYP3A

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dc.authorid0000-0002-0107-0110
dc.authorid0000-0002-6949-9191
dc.authorid0000-0002-8754-2528
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorTurna, Sema
dc.contributor.authorSapmaz, Canan
dc.contributor.authorArınç, Emel
dc.contributor.authorKarakaş, Serpil Yenisoy
dc.date.accessioned2021-06-23T19:35:53Z
dc.date.available2021-06-23T19:35:53Z
dc.date.issued2014
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe primary objective of this study was to determine specific cytochrome P450 isozyme(s) involved in the metabolism of aldrin to its toxic metabolite dieldrin in flathead mullet (Mugil cephalus) liver microsomes. To identify the cytochrome P450 isozyme responsible for the aldrin metabolism in mullet liver, the effects of mammalian-specific cytochrome P450 inhibitors and substrates were determined in the epoxidation reaction of aldrin. CYP3A-related inhibitors, ketoconazole, SKF-525A, and cimetidine, inhibited the metabolism of aldrin. The contribution of CYP1A to the aldrin metabolism was shown by the inhibition of 7-ethoxyresorufin-O-deethylase activity in the presence of aldrin. The results indicate that CY1A and CYP3A are the cytochrome P450s involved in aldrin epoxidase activity in mullet. In addition, the suitability of aldrin epoxidase activity for monitoring of environmental pollution was also assessed in the fish samples caught from four different locations of the West Black Sea coast of Turkey.en_US
dc.identifier.doi10.1002/jbt.21563
dc.identifier.endpage280en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue6en_US
dc.identifier.pmid24756956en_US
dc.identifier.scopus2-s2.0-84902256121en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.21563
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7886
dc.identifier.volume28en_US
dc.identifier.wosWOS:000337621400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozcaarmutlu, Azra
dc.institutionauthorTurna, Sema
dc.institutionauthorSapmaz, Canan
dc.institutionauthorKarakaş, Serpil Yenisoy
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAldrinen_US
dc.subjectBlack Seaen_US
dc.subjectCYP1Aen_US
dc.subjectCYP3Aen_US
dc.subjectFlathead Mullet (Mugil cephalus)en_US
dc.titleAldrin epoxidation in flathead Mullet (Mugil cephalus) : possible involvement of CYP1A and CYP3Aen_US
dc.typeArticleen_US

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