Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?

dc.authorid0000-0002-3063-8748en_US
dc.authorid0000-0003-3719-9482en_US
dc.authorid0000-0003-3726-5945en_US
dc.authorid0000-0002-3896-0934en_US
dc.contributor.authorKekilli, Murat
dc.contributor.authorTanoğlu, Alpaslan
dc.contributor.authorSakin, Yusuf Serdar
dc.contributor.authorKurt, Mevlüt
dc.contributor.authorÖcal, Serkan
dc.date.accessioned2021-06-23T19:42:06Z
dc.date.available2021-06-23T19:42:06Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: To determine the association between the neutrophil to lymphocyte (N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B (CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant. RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean (N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis. CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB.en_US
dc.identifier.doi10.3748/wjg.v21.i18.5575
dc.identifier.endpage5581en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue18en_US
dc.identifier.pmid25987782en_US
dc.identifier.startpage5575en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v21.i18.5575
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8340
dc.identifier.volume21en_US
dc.identifier.wosWOS:000354800200017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Mevlüt
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectLiver Fibrosisen_US
dc.subjectNeutrophil to Lymphocyte Ratioen_US
dc.subjectFibrotic Stageen_US
dc.subjectInflammatory Activityen_US
dc.subjectNon-invasive Markeren_US
dc.titleIs the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?en_US
dc.typeArticleen_US

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