Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?
dc.authorid | 0000-0002-3063-8748 | en_US |
dc.authorid | 0000-0003-3719-9482 | en_US |
dc.authorid | 0000-0003-3726-5945 | en_US |
dc.authorid | 0000-0002-3896-0934 | en_US |
dc.contributor.author | Kekilli, Murat | |
dc.contributor.author | Tanoğlu, Alpaslan | |
dc.contributor.author | Sakin, Yusuf Serdar | |
dc.contributor.author | Kurt, Mevlüt | |
dc.contributor.author | Öcal, Serkan | |
dc.date.accessioned | 2021-06-23T19:42:06Z | |
dc.date.available | 2021-06-23T19:42:06Z | |
dc.date.issued | 2015 | |
dc.department | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.description.abstract | AIM: To determine the association between the neutrophil to lymphocyte (N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B (CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant. RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean (N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis. CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. | en_US |
dc.identifier.doi | 10.3748/wjg.v21.i18.5575 | |
dc.identifier.endpage | 5581 | en_US |
dc.identifier.issn | 1007-9327 | |
dc.identifier.issn | 2219-2840 | |
dc.identifier.issue | 18 | en_US |
dc.identifier.pmid | 25987782 | en_US |
dc.identifier.startpage | 5575 | en_US |
dc.identifier.uri | https://doi.org/10.3748/wjg.v21.i18.5575 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/8340 | |
dc.identifier.volume | 21 | en_US |
dc.identifier.wos | WOS:000354800200017 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Kurt, Mevlüt | |
dc.language.iso | en | en_US |
dc.publisher | Baishideng Publishing Group Inc | en_US |
dc.relation.ispartof | World Journal Of Gastroenterology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Chronic Hepatitis B | en_US |
dc.subject | Liver Fibrosis | en_US |
dc.subject | Neutrophil to Lymphocyte Ratio | en_US |
dc.subject | Fibrotic Stage | en_US |
dc.subject | Inflammatory Activity | en_US |
dc.subject | Non-invasive Marker | en_US |
dc.title | Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B? | en_US |
dc.type | Article | en_US |
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