Serum neuron-specific enolase (NSE) and homocysteine levels in obtructive sleep apnea syndrome (OSAS)

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dc.authorid0000-0002-0437-5075
dc.contributor.authorErgün, Pınar
dc.contributor.authorÇiftçi, Bülent
dc.contributor.authorErgün, Rüçhan
dc.contributor.authorErdoğan, Yurdanur
dc.contributor.authorTuray, Ülkü Yılmaz
dc.contributor.authorGezici, Ali Rıza
dc.date.accessioned2021-06-23T19:26:40Z
dc.date.available2021-06-23T19:26:40Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Presence of a biochemical marker of cerebral injury would be of great benefit in obstructive sleep apnea syndrome (OSAS) to screen for even small brain damage and to monitor efficacy of therapy. The aim of this study was to evaluate whether two different parameters in serum, neuron-specific enolase (NSE) and homocysteine, can be used to detect even subtle levels of cerebral injury in OSAS patients. Material and Methods: We studied 38 patients with OSAS and 30 control subjects with an apnea-hypopnea index (AHI) less than five events per hour. All were evaluated by full-night polysomnography, and in the following morning, serum levels of NSE and homocysteine levels were measured using standard techniques. Results: The AHI in OSAS group was 39.2 +/- 13.8 (mean +/- SD) AH/h. Serum NSE levels were significantly higher in OSAS group (12.3 +/- 5.0 ng/ml) than in the control group (8.2 +/- 1.9 ng/ml; p< 0.01). No significant difference was detected between the groups with regard to serum homocysteine levels (14.1 +/- 6.3 v 14.6 +/- 4.8 mu mol/L; p> 0.05). Conclusion: Elevated serum NSE levels were much more correlated with the severity of OSAS, whereas homocysteine levels were in normal range in these OSAS cases who were otherwise healthy. We believe that there is a need for more sensitive biochemical markers and methods for detecting small cerebral injury in patients with sleep apnea syndrome.en_US
dc.identifier.doi10.5336/medsci.2009-13868
dc.identifier.endpage1890en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-78650958249en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1884en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2009-13868
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6619
dc.identifier.volume30en_US
dc.identifier.wosWOS:000287053500014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErgün, Rüçhan
dc.institutionauthorGezici, Ali Rıza
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Markersen_US
dc.subjectBrain Injuriesen_US
dc.subjectHomocysteineen_US
dc.subjectPhosphopyruvate Hydrataseen_US
dc.subjectSleep Apnea, Obstructiveen_US
dc.titleSerum neuron-specific enolase (NSE) and homocysteine levels in obtructive sleep apnea syndrome (OSAS)en_US
dc.typeArticleen_US

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