Polysaccharide drug delivery systems based on pectin and chitosan

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dc.authorid0000-0002-0335-2162en_US
dc.authorid0000-0003-2588-6349en_US
dc.authorid0000-0002-7798-9692en_US
dc.authorid0000-0002-7050-4082
dc.contributor.authorMorris, Gordon A.
dc.contributor.authorKök, Mehmet Şamil
dc.contributor.authorHarding, Stephen E.
dc.contributor.authorAdams, Gary G.
dc.date.accessioned2021-06-23T19:27:17Z
dc.date.available2021-06-23T19:27:17Z
dc.date.issued2010
dc.departmentBAİBÜ, Mühendislik Fakültesi, Gıda Mühendisliği Bölümüen_US
dc.description.abstractChitosans and pectins are natural polysaccharides which show great potential in drug delivery systems. Chitosans are a family of strongly polycationic derivatives of poly-N-acetyl-Dglucosamine. This positive charge is very important in chitosan drug delivery systems as it plays a very important role in mucoadhesion (adhesion to the mucosal surface). Other chitosan based drug delivery systems involve complexation with ligands to form chitosan nanoparticles with can be used to encapsulate active compounds. Pectins are made of several structural elements the most important of which are the homogalacturonan (HG) and type I rhamnogalacturonan (RG-I) regions often described in simplified terms as the "smooth" and "hairy" regions respectively. Pectin HG regions consist of poly-glacturonic acid residues which can be partially methyl esterified. Pectins with a degree of methyl esterification (DM) > 50% are known as high methoxyl (HM) pectins and consequently low methoxyl (LM) pectins have a DM < 50%. Low methoxyl pectins are of particular interest in drug delivery as they can form gels with calcium ion (Ca2+) which has potential applications especially in nasal formulations. In this chapter we will discuss the physicochemical properties of both chitosans and pectins and how these translate to current and potential drug delivery systems.en_US
dc.identifier.doi10.1080/02648725.2010.10648153
dc.identifier.endpage283en_US
dc.identifier.isbn978-1-908062-02-4
dc.identifier.issn0264-8725
dc.identifier.issn2046-5556
dc.identifier.pmid21415901en_US
dc.identifier.scopus2-s2.0-79551579900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1080/02648725.2010.10648153
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6780
dc.identifier.volume27en_US
dc.identifier.wosWOS:000286179900011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKök, Mehmet Şamil
dc.language.isoenen_US
dc.publisherNottingham Univ Pressen_US
dc.relation.ispartofBiotechnology And Genetic Engineering Reviews, Vol 27en_US
dc.relation.ispartofseriesBiotechnology & Genetic Engineering Reviews
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Anahtar Kelime Yok]en_US
dc.titlePolysaccharide drug delivery systems based on pectin and chitosanen_US
dc.typeReview Articleen_US

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