Minoxidil reduces testicular damage in experimental testicular ischemia/reperfusion injury

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dc.authorid0000-0001-5608-5742
dc.authorid0000-0001-6768-1275
dc.authorid0000-0002-8212-7149
dc.authorid0000-0002-7006-3125
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorYis, Özgür Mehmet
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorCevizci, Nuri
dc.contributor.authorÖztürk, Hülya
dc.date.accessioned2021-06-23T19:53:52Z
dc.date.available2021-06-23T19:53:52Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractWe investigated the effects of K-ATP channel opener minoxidil on oxidant stress, antioxidant defense and histopathological damage in testicular torsion-induced rats. A total of 21 male Wistar-Albino rats were used. Group 1 (the sham-control): the left testis and spermatic cord were only released with a scrotal incision. Group 2 (I/R-untreated): the left testis and spermatic cord was rotated clockwise by 720 degrees for 60 minutes and detorsioned for 60 minutes. Group 3 (I/R-minoxidil treated): Testicular torsion was created as in the group 2 rats and 0.3 mg /kg minoxidil was injected. The testes were extracted for biochemical and histopathological examination.Minoxidil treatment showed a significant decrease in MDA and MPO levels. In the group 2, there was a decrease in TAS levels and an increase in TOS levels. Minoxidil treatment resulted in an improvement of these values in the testicular tissues. There was an improvement in the testicular injury score with minoxidil treatment. The group 2 rats had grade III and grade IV lesions. The treatment with minoxidil showed lower histopathologic features in the testicular tissues. Minoxidil may play a protective role in reducing damage caused by reperfusion of the ischemic testicular tissues.en_US
dc.identifier.endpage2961en_US
dc.identifier.issn1811-9506
dc.identifier.issn2218-3973
dc.identifier.issue4en_US
dc.identifier.startpage2955en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10308
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000616582900043
dc.identifier.volume17en_US
dc.identifier.wosWOS:000616582900043en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorYis, Özgür Mehmet
dc.institutionauthorÖztürk, Hülya
dc.language.isoenen_US
dc.publisherInnovative Scientific Information & Services Networken_US
dc.relation.ispartofBioscience Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTestes Torsionen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectMinoxidilen_US
dc.subjectRatsen_US
dc.titleMinoxidil reduces testicular damage in experimental testicular ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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