Investigation of the pharmacological, behavioral and biochemical effects of boron on rats with rotenone-induced Parkinson's Disease

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dc.authorid0000-0003-1075-9574
dc.authorid0009-0006-8703-8440
dc.authorid0000-0003-2754-6030
dc.authorid0000-0002-7695-3049
dc.authorid0000-0002-1139-942X
dc.authorid0000-0003-4121-1771
dc.authorscopusid7004290487
dc.authorscopusid57211217097
dc.authorscopusid6602550975
dc.authorscopusid23471490500
dc.authorscopusid55898863200
dc.authorscopusid57222050900
dc.authorscopusid58108730400
dc.contributor.authorÖzdemir, Hülya Sağmanlıgil
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorSağmanlıgil, Vedat
dc.contributor.authorYaşar, Semih
dc.contributor.authorÇölçimen, Neşe
dc.contributor.authorGöçeroğlu, Rezzan Temelli
dc.contributor.authorÇatalkaya, Ege
dc.date.accessioned2024-09-25T19:42:57Z
dc.date.available2024-09-25T19:42:57Z
dc.date.issued2023
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractParkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system. In different studies, it has been investigated that boric acid has positive effects on different mechanisms that are important in PD. The aim of our study was to investigate the pharmacological, behavioral and biochemical effects of boric acid on rats with experimental PD with Rotenone. For this purpose, Wistar-albino rats were divided into 6 groups. Only normal saline was applied subcutaneously (s.c) to the first control and sunflower oil to the second control group. Rotenone was administered (s.c) to 4 groups (groups 3-6) at a dose of 2 mg/kg for 21 days. Only rotenone (2mg/kg, s.c) was administered to the third group. Boric acid was administered intraperitoneally (i.p.) at 5 mg/kg, 10 mg/kg, and 20 mg/kg to groups 4, 5, and 6, respectively. During the study, behavioral tests were applied to the rats, and then histopathological and biochemical analyzes were performed from the sacrificed tissues. According to the data obtained, a statistically significant difference (p<0.05) was observed between the Parkinson's group and the other groups in motor behavior tests, excluding the catalepsy test. Boric acid exhibited dose-dependent antioxidant activity. As a result of the histopathological and immunohistochemical (IHC) examination, a decrease in neuronal degeneration was observed at the increasing doses of boric acid, while gliosis and focal encephalomalacia were rarely encountered. There was a significant increase in tyrosine hydroxylase (TH) immunoreactivity, especially in group 6, with a dose of 20 mg/kg of boric acid. From these results, we conclude that the dose-dependent effect of boric acid may protect the dopaminergic system with antioxidant activity in the pathogenesis of PD. However, the effectiveness of boric acid on PD needs further investigation in a larger, more detailed study using different methods. Copyright: © 2022 by the C.M.B. Association. All rights reserved.en_US
dc.description.sponsorshipVan YuzuncuYil University, (TSA-2020-8960)en_US
dc.identifier.doi10.14715/cmb/2022.68.8.3
dc.identifier.endpage21en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue8en_US
dc.identifier.pmid36800846en_US
dc.identifier.scopus2-s2.0-85148399883en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2022.68.8.3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12377
dc.identifier.volume68en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunusoğlu, Oruç
dc.institutionauthorid0000-0003-1075-9574
dc.language.isoenen_US
dc.publisherCellular and Molecular Biology Associationen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAntioxidant Capacityen_US
dc.subjectBehaviouren_US
dc.subjectImmunohistochemical Activityen_US
dc.subjectParkinsonen_US
dc.subjectRotenoneen_US
dc.titleInvestigation of the pharmacological, behavioral and biochemical effects of boron on rats with rotenone-induced Parkinson's Diseaseen_US
dc.typeArticleen_US

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