Effect of chronic obstructive pulmonary disease on washout time of sevoflurane anesthesia: a placebo controlled randomized trial

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dc.authorid0000-0002-1441-6360en_US
dc.authorid0000-0003-0811-4945
dc.authorid0000-0002-0732-8952
dc.authorid0000-0001-5790-2337
dc.authorid0000-0003-2954-4784
dc.contributor.authorŞeker, İlknur Suidiye
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorHaftacı, Engin
dc.contributor.authorCangür, Şengül
dc.contributor.authorSezen, Gülbin
dc.contributor.authorKaragöz, İbrahim
dc.date.accessioned2021-06-23T19:44:16Z
dc.date.available2021-06-23T19:44:16Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Respiratory functions and gas exchange deteriorates in patients with COPD. In our study, we aimed to investigate if there is any relationship between the washout time of sevoflurane and chronic obstructive pulmonary disease (COPD). Method: Sixty patients, American Society of Anesthesiology (ASA) 1-3 status; aged between 18-60 years old who underwent general anesthesia for an operation were enrolled in our study. Patients were divided into two groups: Group N (non-COPD n = 33), group COPD (patients with COPD, n = 33). Two patients were excluded from the study, a total of 31 patients in Group COPD. Pre-operative respiratory function tests were performed and standard monitoring was provided in the operation room. Both groups received propofol 2 mg/kg, fentanyl 1.5-2 mcg/kg and rocuronium 0.6 mg/kg intravenously, and an oxygen-air mixture of 50%/50% with a tidal volume of 6 ml/kg (ideal body weight) and sevoflurane of 1 MAC. Remifentanil was administered at 0.05-0.1 mcg/ kg/min intravenously in the maintenance of anesthesia. All patients were monitored by an anesthesia machine until extubation. A sevoflurane vaporizer was closed at the end of the operation and the measurement time was started. FiO2, Fi(ins), Fi(exp) of sevorain, End-tidal CO2 were recorded during the operation and Fins (Sevo)/Fexp (Sevo) ratio, MAC1, MAC2, MAC3, MAC4, extubation times were recorded. Fi(ins)1: percentage of sevorain filiation in inspirium before closing 1 MAC vaporizer. Fi(exp)1: percentage of sevorain filiation in expirium before closing 1 MAC vaporizer. Fi(ins)2: percentage of sevorain filiation in inspirium after closing 0.1 MAC vaporizer. Fi(exp)2: percentage of sevorain filiation in expirium after closing 0.1 MAC vaporizer. Results: There was no significant relationship between the respiratory function tests of individuals with or without COPD and MAC1, MAC2, MAC3, MAC4 and extubation time (P > 0.05). The cut-off criterion for MAC4 was determined to be 210 seconds. Conclusion: Although there was no difference between the washout and extubation times of both groups, increased BMI and decreased intraoperative hemoglobin values should be carefully considered during anesthetic management in the COPD group.en_US
dc.identifier.endpage14967en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-84985918720en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage14959en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8951
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000386428400326
dc.identifier.volume9en_US
dc.identifier.wosWOS:000386428400326en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaragöz, İbrahim
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSevofluraneen_US
dc.subjectCOPDen_US
dc.subjectWashout Timeen_US
dc.subjectGas Exchangeen_US
dc.subjectAnesthesiaen_US
dc.titleEffect of chronic obstructive pulmonary disease on washout time of sevoflurane anesthesia: a placebo controlled randomized trialen_US
dc.typeArticleen_US

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