Evaluation of general characteristics of renal cell carcinoma patients: A single center experience

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dc.authorid0000-0002-6839-2632
dc.authorid0000-0002-4242-9134
dc.authorid0000-0001-5588-0306
dc.authorid0000-0002-4313-8478
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorYılmaz, Burak
dc.contributor.authorKüçüköztaş, Nadire
dc.contributor.authorÜyetürk, Uğur
dc.date.accessioned2021-06-23T18:43:00Z
dc.date.available2021-06-23T18:43:00Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Renal cancer (RC) accounts for 3.2% of all newly diagnosed cancers and approximately 90% of RC cases are renal cell carcinoma (RCC). Smoking and hypertension are the most important risk factors. The aim of our study was to evaluate the general characteristics of RCC patients in Bolu, Turkey. Materials and Methods: Patients who visited our medical oncology clinic and were diagnosed with RCC between January 1st, 2012 and May 31st, 2017 were evaluated retrospectively. Results: Eighty-one patients were diagnosed with RCC during the study period. The median age of the patients was 62 years (range: 38-87 years). Fifty-seven (70.4%) of the patients were male and 24 (29.6%) were female. Thirty patients (37.1%) were diagnosed incidentally. Forty-eight (59.3%) of the patients were smokers. The most common comorbidity was hypertension (58%). Radical nephrectomy was performed in 59 (72.8%) of the patients. The most common histological subtype was clear cell carcinoma (72.8%) and 39 (48.1%) were stage 1 when evaluated according to the stage of RCC. Of the 16 patients with metastatic disease, 11 (13.6%) received interferon therapy, and 5 patients (6.2%) refused treatment. After interferon treatment, 7 patients received targeted therapy with sunitinib/pazopanib as second-line treatment, 5 received everolimus as third-line treatment, and 3 received axitinib treatment as fourth-line treatment. Ten patients with bone metastasis underwent palliative radiotherapy. The median follow-up time of the patients was 21 months (0-123 months). Sixty-five patients (80.2%) survived this period. Conclusion: Smoking cessation and effective treatment of hypertension, preventable etiological factors of RCC, and incidental diagnosis of early RCC are very important. With early diagnosis, the partial nephrectomy rate might be increased.en_US
dc.identifier.doi10.4274/uob.957
dc.identifier.endpage48en_US
dc.identifier.issn2147-2122
dc.identifier.issn2147-2270
dc.identifier.issue2en_US
dc.identifier.startpage45en_US
dc.identifier.trdizinid307806en_US
dc.identifier.urihttps://doi.org/10.4274/uob.957
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpBM09EQTJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3717
dc.identifier.volume17en_US
dc.identifier.wosWOS:000435400300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÜyetürk, Ümmügül
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorYılmaz, Burak
dc.institutionauthorKüçüköztaş, Nadire
dc.institutionauthorÜyetürk, Uğur
dc.language.isoenen_US
dc.relation.ispartofÜroonkoloji Bültenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectEtiologyen_US
dc.subjectBolu
dc.titleEvaluation of general characteristics of renal cell carcinoma patients: A single center experienceen_US
dc.typeArticleen_US

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